Methylmalonic Acidemia Cobalamin Disorders (MMA Cbl A, B)


Methylmalonic acidemia cobalamin disorders (MMA Cbl A or B) are inborn errors of metabolism, inherited conditions with different genetic causes. These are organic acid conditions because they can lead to the build-up of harmful amounts of organic acids and toxins in the body. Symptoms can vary and may include feeding and growth problems, anemia, vomiting, extreme tiredness/lethargy, breathing problems, changes in muscle tone, kidney problems and/or other potential signs and symptoms. Early detection and prompt and ongoing management can benefit children living with one of these conditions. Support groups are available to help connect families living with methylmalonic acidemia cobalamin disorders (MMA Cbl A or B) with others who have experience or expertise with organic acid conditions.

To learn more about Methylmalonic acidemia Cobalamin disorders, visit Screening, Technology, and Research in Genetics (STAR-G): Methylmalonic acidemia. Please see Medically Prescribed Formula for information about medically prescribed formula and pharmacologic interventions for inborn errors of metabolism. A listing of contact information for Minnesota inborn errors of metabolism medical specialty providers/clinics serving children affected with or undergoing evaluation for conditions that can be detected through Minnesota Newborn Screening is available upon request.