Short Chain Acyl-CoA Dehydrogenase (SCAD) Deficiency
Short chain acyl-CoA dehydrogenase (SCAD) deficiency is an inborn error of metabolism, an inherited condition in which an enzyme, short-chain acyl-CoA dehydrogenase, in the body is either missing or not working well. The job of this enzyme is to help break down certain fats, and when the enzyme is not working properly certain substances build up in the body. SCAD deficiency is considered a fatty acid oxidation condition because people with SCAD deficiency are unable to change some fats into energy. Findings in individuals identified as having SCAD deficiency are variable; some have not experienced symptoms and others have had serious health problems. Long-term follow up of individuals with SCAD deficiency may help increase understanding of this condition. Support groups are available to help connect families living with SCAD deficiency with others who have experience or expertise with this condition.
To learn more about Short-chain acyl-CoA dehydrogenase deficiency, visit Screening, Technology, and Research in Genetics (STAR-G): Short-chain acyl-CoA dehydrogenase deficiency and Baby's First Test: Short-chain acyl-CoA dehydrogenase deficiency. Please see Medically Prescribed Formula for information about medically prescribed formula and pharmacologic interventions for inborn errors of metabolism. A listing of contact information for Minnesota inborn errors of metabolism medical specialty providers/clinics serving children affected with or undergoing evaluation for conditions that can be detected through Minnesota Newborn Screening is available upon request.