Poster Presentations on the Alternative Risk Assessment Methods Project - EH: Minnesota Department of Health

Poster Presentations on the Alternative Risk Assessment Methods Project

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Providing Risk Context for Water Contaminants with Minimal or No Toxicity Data

Alternative approaches for evaluating and providing risk context for water contaminants with minimal toxicity data

Title: Providing Risk Context for Water Contaminants with Minimal or No Toxicity Data

Authors: Helen Goeden, Martin Phillips, Ashley Suchomel, Naida Gavrelis, Liz Bertelsen, Wendy Heiger-Bernays

Presented at: Society of Toxicology, 2015 Annual Meeting

Abstract: The Minnesota Department of Health (MDH) is tasked with determining human health risks from exposure to contaminants in drinking water. In conducting this work, MDH relies upon standard risk assessment methodologies to derive health-based guidance. Traditional risk assessment methods, however, require chemical-specific toxicity data in order to develop numerical guidance. Advancement in analytical methods has led to the detection of many unregulated contaminants. These contaminants often have little or no publically available toxicological data, making it difficult to sufficiently evaluate the chemical using traditional risk assessment methods. To develop appropriate public health responses, MDH, with funding provided through the State of Minnesota Clean Water Fund of the Clean Water, Land and Legacy Amendment, identified risk-based methods that could be used to provide risk context for chemicals with minimal toxicity data. MDH worked with partners to critically review and test a range of published “generic” screening methods (e.g., threshold of toxicological concern), extrapolation methods and computational tools. Initial findings identified three toxicological endpoints for which available methods and tools may not be sufficiently protective: genotoxic carcinogenicity; cholinesterase inhibition and endocrine disruption. This finding, along with method testing results, was used to develop a systematic decision framework for evaluating contaminants in water. The framework provides a stepwise assessment process starting with chemical-specific structure and conservative benchmark values and progressing to more in-depth assessment depending upon the availability of toxicity information and predictive models (e.g., QSAR, biological, and hybrid models). MDH plans to use this decision framework to prioritize research needs and provide risk context for contaminant occurrence data, including chemical-specific drinking water guidance when possible.

Poster in PDF Format of Providing Risk Context for Water Contaminants with Limited or No Toxicity Data

Title: Alternative approaches for evaluating and providing risk context for water contaminants with minimal toxicity data

Authors: Helen Goeden, Ashley Suchomel, Naida Gavrelis, Liz Bertelsen, Wendy Heiger-Bernays, Dale Hattis

Presented at: Society for Risk Analysis, 2014 Annual Meeting

Abstract: The State of Minnesota monitors for contaminants of emerging concern (CECs) such as pharmaceuticals, personal care and household products, and unregulated industrial chemicals. The Minnesota Department of Health (MDH) is tasked with determining human health risks from exposure to contaminants in drinking water. Traditional risk assessment methods require chemical-specific toxicity data in order to develop numerical health-based guidance values for drinking water. However, many CECs have little to no available toxicological data, making it difficult to sufficiently evaluate the chemical. In order to develop appropriate public health responses, MDH, with funding provided through the State of Minnesota Clean Water Fund of the Clean Water, Land and Legacy Amendment, identified risk assessment methods that can be used with a minimum amount of toxicity data. MDH worked with partners to critically review and test a range of published “generic” screening methods (e.g., threshold of toxicological concern), extrapolation methods, computational tools and the underlying databases (e.g., QSAR tools), and to assess method uncertainties and limitations. The findings were used to develop a systematic decision framework for evaluating contaminants in water. The framework is based on chemical-specific structure/structural alerts and associated toxicological endpoints and also incorporates open-access computational toxicology resources. Through rigorous testing, MDH and partners have evaluated the capacity of the framework to address a wide variety of substances and adverse health endpoints. In addition, the overall compatibility of the framework and existing MDH and other state of the science risk assessment principles and practices was evaluated. MDH will use this decision framework to provide risk context for contaminant occurrence data, develop protective chemical-specific human health guidance, and prioritize contaminants for more in-depth analysis.

Poster in PDF Format of Alternative approaches for evaluating and providing risk context for water contaminants with minimal toxicity data

 

Updated Friday, September 11, 2015 at 11:17AM