Clostridium Difficile Infection Prevention
- Infection Control
Guidelines and information about preventing and controlling infectious disease transmission.
News and Alerts | Guidelines | Healthcare-Associated Infections | Precautions | National Healthcare Safety Network | Personal Protective Equipment | Respiratory Protection Program | For Public Safety Personnel
Implementation of CDI surveillance
- Surveillance programs are an important measure used to detect and prevent outbreak of C. difficile within healthcare facilities. Surveillance programs should fit the needs of your facility while incorporating:
- Patient care rounds to identify patients with signs and symptoms of CDI
- Standardized processes for laboratory testing, diagnosis and communication
- Place patients in a private room
- Cohort patients if private room is not available
- Patients with discordant status of infection or colonization with other epidemiologically important organisms (e.g., VRE and MRSA) are not cohorted.
- If one patient resolves diarrhea, transfer to clean room
- If multi-patient rooms are necessary, place spatial separation (minimum 3 feet) between beds; may use privacy curtain or place tape on floor for visual queue.
- Communicate isolation precautions status
- Dedicate equipment whenever possible
- Use gloves when entering patients’ rooms and during patient care
- Use gowns if soiling clothes is likely
- Change gloves and gowns and perform hand hygiene when moving from one patient to another when patients are cohorted
- Practice hand hygienefollowing CDC or WHO recommendations
- Alcohol-based hand rubs are NOT effective against spore-forming organisms such as C. difficile
- If an institution is experiencing an outbreak of CDI, hand hygiene should be performed with soap and water after caring for patients with CDI
- Alcohol-based hand rubs can be used for routine hand hygiene when caring for other patients
- Continue precautions until CDI symptoms have resolved (e.g., patient has <3 stools in a 24 hour periods)
Isolation precautions
Rooming
Personal Protective Equipment
Environmental cleaning and disinfection
- CDI patient rooms and patient care equipment are appropriately cleaned and disinfected.
- High touch areas need to be targeted for proper disinfection. These areas include but are not limited to:
- Door knobs/handles
- Door surfaces
- Bed rails
- Call button
- Phone
- Overbed table and drawer
- Countertop
- Light switches
- Furniture
- Arms and seat of patient chair
- Window sills
- Bedside commode
- Medical equipment (e.g., IV controls)
- Use a hospital grade Environmental Protection Agency (EPA)-registered hypochlorite-based disinfectant for environmental surface disinfection after cleaning in accordance with label instructions.
- Follow the manufacturer’s instructions for disinfection of endoscopes and other devices.
- Patient care equipment is dedicated to one patient or cleaned/disinfected between patients.
Antimicrobial stewardship
- Programs should incorporate a process that monitors and evaluates antimicrobial use and provides feedback to medical staff and facility leadership.
- Antimicrobial Agent Use
IDSA antimicrobial agent resource list. Attention: Non-MDH link. - Antimicrobial Resistance
MDH antimicrobial resistance website.
- Antimicrobial Agent Use
For Long Term Care Facilities
- Infection control practices in long term care and home health settings are similar to those practices taken in traditional health-care settings.


