Hepatitis G Virus Fact Sheet
(adapted from materials developed by the Centers for Disease Control and Prevention)
On this page:
Report to Minnesota Department of Health
Signs and Symptoms
Treatment and Medical Management
Trends and Statistics
- Hepatitis G virus (HGV) is a rare cause of hepatic inflammation. Although chronic infection and viremia have been documented, histologic evidence is rare, and serum aminotransferase levels are usually normal. At this time, reporting of HGV to the Minnesota Department of Health would be treated as anecdotal.
- HGV is a single-stranded RNA virus classified in the Flaviviridae family; the virus shares 27% homology with hepatitis C virus (HCV).
- The name HGV denotes two independent viruses: HGV and GBV-C. The HGV has not yet been isolated.
- The liver is not a significant site of replication.
- Most infected persons are asymptomatic.
- Incubation period is unknown.
- HGV can cause chronic infection and viremia; however, there is no conclusive evidence to indicate that HGV causes fulminant or chronic liver disease.
- Co-infection with hepatitis B virus (HBV) or HCV does not seem to worsen the course or severity of disease.
- Blood and sexual contact
- Transplacental, rarely
- Transfusion and organ transplant recipients
- Injection drug users
- Hemodialysis patients
- Men who have sex with men
- No specific measures have been identified.
- Currently, no serologic test is available.
- PCR tests for HGV are not widely available.
- None indicated.
- Not known.
- HGV has been reported in adults and children throughout the world and is found in about 1.5% of blood donors in the United States.
- Infection has been reported in 10% to 20% of adults with chronic HBV or HCV infection, indicating that co-infection is a common occurrence.
- Pickering L, eds. “Red Book 2000 Report of the Committee on Infectious Diseases, 25th ed.” 2000, American Academy of Pediatrics.