Pneumococcal Polysaccharide Vaccine (PPSV)

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PPSV for adults
PPSV for kids
General PPSV information

PPSV for adults

Pneumococcal 23-valent polysaccharide vaccine (PPSV) protects against serious infections caused by 23 type of pneumococcal infection. A maximum of two PPSV doses in a lifetime is all that is recommended. This vaccine is recommended for:

  • All adults age 65 years or older, or

  • Persons 2 through 64 years with any of the following:
    • Chronic cardiovascular disease (e.g., CHF, cardiomyopathies)
    • Chronic pulmonary disease (e.g., emphysema or COPD, including asthma)
    • Cigarette smokers age 19 through 64 years
    • Chronic liver disease, including persons with long-term alcoholism
    • Diabetes mellitus
    • CSF leaks
    • Functional or anatomic asplenia (e.g., sickle cell disease or splenectomy)
    • Immunosuppressive conditions (e.g., HIV infection, leukemia, congenital immunodeficiency, Hodgkin’s disease, lymphoma, multiple myeloma, or generalized malignancy)
    • Organ or bone marrow transplantation
    • Therapy with alkylating agents, antimetabolites, or systemic corticosteroids
    • Chronic renal failure or nephrotic syndrome
    • Cochlear implants

  • A second dose (revaccination) of PPSV is recommended for:
    • Persons age 2 through 64 years with any of the following: functional or anatomic asplenia, immunosuppression, transplant, chronic renal failure, nephrotic syndrome.
    • Adults age 65 years or older who received the first dose prior to age 65 years.
Spacing between first and second PPSV doses (revaccination)
Age of patient: Spacing between shots:

Age 2 through 9 years

3 years apart
Age 10 through 64 years At least 5 years apart
Age 65 years or older At least 5 years apart

PPSV for kids

  • The PPSV vaccine is particularly recommended for high risk children 2 years and older with any of the following:
    • Chronic cardiovascular disease (e.g., CHF, cardiomyopathies)
    • Chronic pulmonary disease (e.g., emphysema or COPD, including asthma)
    • Chronic liver disease, including persons with long-term alcoholism
    • Diabetes mellitus
    • CSF leaks
    • Functional or anatomic asplenia (e.g., sickle cell disease or splenectomy)
    • Immunosuppressive conditions (e.g., HIV infection, leukemia, congenital immunodeficiency, Hodgkin’s disease, lymphoma, multiple myeloma, or generalized malignancy)
    • Organ or bone marrow transplantation
    • Therapy with alkylating agents, antimetabolites, or systemic corticosteroids
    • Chronic renal failure or nephrotic syndrome
    • Cochlear implants
  • A second dose (revaccination) of PPSV is recommended for:
    • Children 2 years and older with any of the following: functional or anatomic asplenia, immunosuppression, transplant, chronic renal failure, nephrotic syndrome.
Spacing between first and second PPSV doses (revaccination)
Age of patient: Spacing between shots:

Age 2 through 9 years

3 years apart
Age 10 through 64 years At least 5 years apart

General PPV information

Updated Tuesday, November 16, 2010 at 12:21PM