12-Week INH-RPT Regimen for Treatment of Latent TB Infection

In December 2011, the Centers for Disease Control and Prevention (CDC) published recommendations for an additional option for the treatment of latent TB infection (LTBI) in some individuals. This new regimen consists of 12 weekly doses of isoniazid (INH) and rifapentine (RPT). It is intended for use in certain high-risk patients and must be administered as Directly Observed Therapy (DOT) by local health departments. Links to CDC materials about this regimen are listed below.

MDH will supply medications for this regimen through its free TB medications program for patients who meet eligibility criteria and for whom a specific plan is in place to provide monthly physical examinations at a clinic and DOT by the local health department. Local health departments in Minnesota may vary in their ability to provide this service.

  • MDH TB Medications Program
    MDH’s program for providing TB medications free-of-charge for Minnesota residents who are receiving treatment for LTBI or active TB disease.
  • TBeat: HNTC Newsletter
    Frequently Asked Questions issued by Heartland National TB Center on the INH-RPT regimen. They can be found in the newsletter dated March 2012, Volume 7 #1. Attention: Non-MDH link

Updated Wednesday, 28-May-2014 14:23:36 CDT