Carbapenem-resistant Enterobacteriaceae (CRE)
The term CRE refers to carbapenem-resistant and carbapenemase-producing Enterobacteriaceae. Currently, the most common type of carbapenemase in the United States is the Klebsiella pneumoniae carbapenemase (KPC). In 2010, carbapenemases known as metallo-β-lactamases (MBL) were first detected in the U.S.: New Delhi MBL (NDM) and Verona integron-encoded MBL (VIM).
- About CRE
CRE facts including: what CRE are, how CRE are spread, and how to prevent CRE.
CRE Information for Health Professionals:
- CRE Resistance Mechanisms
Information for health care personnel about resistance mechanisms responsible for CRE.
- Surveillance Case Definition and Reporting
CRE surveillance definition and reporting to MDH.
- Laboratory Testing and Protocols
Laboratory testing protocols for CRE and isolate submission to MDH.
- Recommendations for the Management of CRE in Acute and Long-term Acute Care Hospitals
MDH recommendations for the prevention and control of carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae in acute and long-term acute care facilities. (Updated 2/2013)
- Recommendations for the Management of CRE in Long-term Care Facilities
MDH recommendations for the prevention and control of carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae in long-term care facilities.
- Other Guidelines and Resources
Guidelines and resources to prevent CRE transmission in health care facilities.


