CRE Disease Reporting and Surveillance Case Definition
In 2011, as part of the Emerging Infections Program, MDH initiated population-based laboratory surveillance for CRE in Ramsey and Hennepin Counties. CRE is not reportable under the Minnesota Communicable Diseases Reporting Rule.
On this page:
What to report
Who should report
How to report
Submitting clinical materials
What to report: CRE surveillance definition
- Enterobacteriaceae that meet the following criteria should be considered as having met the surveillance defintion:
- Intermediate* or resistant* to imipenem, meropenem, or doripenem; AND
- Resistant* to all tested third generation cephalosporins.
- Some isolates of Morganella, Serratia, Providencia, Hafnia, Proteus, or Yersinia may have different resistance mechanisms that result in elevated imipenem MICs. Therefore, submit these isolates ONLY if they meet the following criteria:
- Intermediate* or resistant* to at least two carbapenem antibiotics (imipenem, meropenem, or doripenem); AND
- Resistant* to all tested third generation cephalosporins.
*The carbapenem and third generation cephalosporin interpretive breakpoints are based on the 2011 Clinical and Laboratory Standards Institute.
Who should to report
- Healthcare providers and laboratories in Hennepin and Ramsey Counties are required to report cases of CRE (patients who are infected or colonized with CRE) to the Minnesota Department of Health.
- All laboratories outside Hennepin and Ramsey Counties are strongly encouraged to voluntarily report CRE to MDH and submit CRE isolates to MDH PHL.
How to report
- Yellow Card
The MDH "Yellow Card" (previously known as the "blue card") can be used to report CRE cases in Minnesota residents to the Minnesota Department of Health . - Submit CRE isolates to MDH PHL.
- Infection preventionists/physicians should notify MDH-Epidemiology when a specimen is submitted (651-201-5414 or 1-877-201-5414) or if you have reporting questions.
Submitting clinical materials
- Laboratory Testing and Protocols
Information about subimitting isolates to MDH PHL.

