The Clinical Guide to Services is a comprehensive reference guide of testing services, shipping information and submission requirements. Efforts have been made to be concise and current with all information, but as testing procedures and regulations change, some information may not be current. Many of these tests are only available with prior approval from MDH. It is impossible to address all situations in this guide, so please contact us with any questions.

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Haemophilus ducreyi - Detection in Clinical Samples

Methodology: culture
Restrictions: Contact the laboratory at (651) 201-5073 before requesting this test.
Fee Sticker: Required
Specimen: Swab of lesion in Amies transport media
Shipping: Ship at refrigeration temperature or on ice. Sample must be delivered to MDH within 24 hours of sample collection. See comments.
Turnaround: Results available following 5 day incubation
Comments: Successful culture of H. ducreyi is dependent on strict observance of collection and transport conditions.

Haemophilus ducreyi - Detection of DNA in Clinical Samples

Methodology: PCR
Restrictions: This test is not currently available. Contact the laboratory at (651) 201-5073 before requesting this test.
Fee Sticker: Not required
Specimen: Swab of lesion in Amies transport media
Shipping: Ship at refrigeration temperature or on ice.
Turnaround: Not available
Comments: This test is for research use only and is performed only in conjunction with culture (see above).

Haemophilus influenzae - Antigen Detection

See: Meningitis, Bacterial

Haemophilus influenzae - Antimicrobial Susceptibility Testing

See: Antimicrobial Susceptibility Testing

Haemophilus influenzae - Identification/Confirmation of Referred Isolate

Methodology: Biochemical testing, Serotyping, Biotyping
Restrictions: None
Fee Sticker: Not required
Specimen: Actively growing pure culture on suitable medium
Shipping: Ship at room temperature.
Turnaround: Identification from pure culture available within 2-3 working days
Invasive disease caused by this agent is reportable. All isolates from cases of invasive disease must be submitted to MDH as required by State Rule 4605.7040

Haemophilus influenzae Type b - Detection of DNA in Clinical Samples

Methodology: PCR
Restrictions: Contact Infectious Disease Epidemiology Prevention and Control at (651) 201-5414 or (877) 676-5414 before requesting this test.
Fee Sticker: Not required
Specimen: CSF (0.5 ml)
Serum (0.5 ml)
Bronchoalveolar lavage, pleural fluid, tracheal aspirate (0.5 ml)
Nasopharyngeal swab, dry or in transport medium
Throat swab, dry or in transport medium
Shipping: Ship at refrigeration temperature.
Turnaround: Not available
Comments: This test is for research use only.
Invasive disease caused by this agent is reportable. All invasive isolates must be submitted to MDH as required by State Rule 4605.7040

Hantavirus - IgM and IgG Antibody Detection

Methodology: Enzyme immunoassay
Restrictions: Contact Infectious Disease Epidemiology Prevention and Control at (651) 201-5414 or (877) 676-5414 before requesting this test
Fee Sticker: Required
Specimen: Serum (1 ml)
Shipping: Ship at refrigeration temperature.
Turnaround: Sent to CDC; no turnaround time available.

This disease must be reported to MDH as required by State Rule 4605.7040

Hemolytic Uremic Syndrome (HUS) - Detection of Agent in Clinical Samples

See also: Escherichia coli, pathogenic, Escherichia coli O157:H7
Methodology: Culture using immunomagnetic separation, PCR
Restrictions: None
Fee Sticker: Required
Specimen: Stool in ParaPak C&S, Modified Carey-Blair or equivalent - fill to line (approximately 5 ml). Unpreserved stool samples must be received within 2 hours of collection.
Other specimen types - contact laboratory
Shipping: Ship preserved samples at room temperature. Transport fresh samples at refrigeration temperature.
Turnaround: Within 2-4 working days of specimen receipt
Comments: If HUS is suspected and E. coli O157 has not been found, send stool specimen and/or serum for additional testing.

This disease is reportable. Isolates must be submitted to MDH as required by State Rule 4605.7040

Herpes simplex Virus - Confirmation/Subtyping

Methodology: Direct fluorescent antibody
Restrictions: None
Fee Sticker: Required
Specimen: Primary virus isolate in tissue culture
Shipping: Ship at room temperature.
Turnaround: Culture results available with 7 days. Subtyping results available within 1 day.

Herpes simplex Virus - Detection in Clinical Samples

See also: Rash Illness Panel
Methodology: Culture, Direct fluorescent antibody
Restrictions: None
Fee Sticker: Required
Specimen: Vesicle lesion in viral transport medium or as described below for PCR
Throat swab in viral transport medium
Genital swab in viral transport medium
Ocular swab in viral transport medium
CSF (1 ml)
Brain tissue
Shipping: Ship at refrigeration temperature.
Turnaround: Culture results available with 7 days. Subtyping results available within 1 day.

Herpes simplex Virus - Detection of DNA in Clinical Samples

See also: Rash Illness Panel
Methodology: PCR
Restrictions: Contact Infectious Disease Epidemiology Prevention and Control at (651) 201-5414 or (877) 676-5414 before requesting this test.
Fee Sticker: Not required
Specimen: Roof of lesion in a sterile container
Swab of lesion, dry or in transport medium
Touch-prep (slide) of vesicular fluid
Other specimens as described for culture/DFA
Shipping: Ship at refrigeration temperature.
Turnaround: Not available
Comments: This test is for research use only.

Herpes zoster

See: Varicella Zoster Virus

Histoplasma capsulatum - Antibody Detection

See: Fungal Serology

Histoplasma capsulatum - Identification/Confirmation of Referred Isolate

Methodology: Culture morphology and conversion, Nucleic acid probe
Restrictions: None
Fee Sticker: Not required
Specimen: Actively growing pure culture on suitable medium
Shipping: Ship at room temperature, sealed culture system.
Turnaround: Probe results within 1 working day.

This disease must be reported to MDH as required by State Rule 4605.7040

HIV

See: Human Immunodeficiency Virus

Hookworm

See: Parasite Examination, Parasite Identification, Parasite Serology

HSV

See: Herpes Simplex Virus

Human Immunodeficiency Virus - Antibody Confirmation + HIV1/HIV2 differentiation

Methodology: Rapid Multispot assay
Restrictions: Contact Infectious Disease Epidemiology Prevention and Control at (651) 201-5414 or (877) 676-5414 before requesting this test.
Fee Sticker: Required
Specimen: Serum (preferred)
Plasma (1 ml)
Shipping: Ship at refrigeration temperature.
Turnaround: 5 days

This disease must be reported to MDH as required by State Rule 4605.7040

Human Immunodeficiency Virus - Viral Antigen p24 + Antibody Detection

Methodology: Enzyme Immunoassay
Restrictions: Contact Infectious Disease Epidemiology Prevention and Control at (651) 201-5414 or (877) 676-5414 before requesting this test.
Fee Sticker: Required
Specimen: Serum (preferred)
Plasma (1 ml)
Shipping: Ship at refrigeration temperature.
Turnaround: 5 days

This disease must be reported to MDH as required by State Rule 4605.7040

Human Metapneumovirus

See: Metapneumovirus, Human