Medical Cannabis Review Articles and Reports on Amyotrophic Lateral Sclerosis

Medical Cannabis Review Articles and Reports on Amyotrophic Lateral Sclerosis

The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research
A report published by the U.S. National Academies of Sciences, Engineering, and Medicine.  2017. 
A rigorous review of relevant scientific research published since 1999, summarizing the current state of evidence regarding what is known about the health impacts of cannabis and cannabis-derived products, including effects related to therapeutic uses of cannabis and potential health risks related to certain cancers, diseases, mental health disorders, and injuries.  Sections on evidence of therapeutic effects include: chronic pain, cancer treatment, chemotherapy-induced nausea and vomiting, anorexia and weight loss associated with HIV/AIDS, cancer-associated anorexia-cachexia syndrome, anorexia nervosa, irritable bowel syndrome, epilepsy, spasticity associated with multiple sclerosis or spinal cord injury, Tourette syndrome, amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, dystonia, dementia, glaucoma, traumatic brain injury/intracerebral hemorrhage, substance addiction, anxiety, depression, sleep disorders, posttraumatic stress disorder, and schizophrenia and other psychoses.  Chapters summarizing evidence of harms include: cancer, cardiometabolic risk, respiratory disease, immunity, injury and death, prenatal/perinatal/neonatal exposure, psychosocial, mental health, cannabis use problems, and abuse of other substances.

A Review of Medical Cannabis Studies relating to Chemical Compositions and Dosages for Qualifying Medical Conditions (PDF)
Office of Medical Cannabis.
Summary of clinical trials and prospective observational studies in humans, published in peer-reviewed journals, which focus on medical cannabis formulations consistent with Minnesota’s medical cannabis program.

Information for Health Care Professionals: Cannabis and the cannabinoids (PDF)
Health Canada. February, 2013.
Endocannabinoid system, clinical pharmacology, dosing, potential therapeutic uses (by condition), precautions, warnings, adverse effects, and overdose/toxicity.

Handbook of Cannabis
Roger G Pertwee, Oxford University Press, 2014. 747 pages.

  • Constituents, History, International Control, Cultivation, and Phenotypes of Cannabis
  • Pharmacology, Pharmacokinetics, Metabolism, and Forensics
  • Medical Cannabis and Cannabinoids: Clinical Data
  • Approved Therapeutic Targets for Phytocannabinoids: Preclinical Pharmacology
  • Some Potential Therapeutic Targets for Phytocannabinoids
  • Recreational Cannabis: Sought-After Effects, Adverse Effects, Designer Drugs, and Harm Minimization

Complementary and Alternative Therapies in Amyotrphic Lateral Sclerosis
Bedlack RS, Joyce N, Carter GT, Pagononi S, Karam C. Neurol Clin 2015;33:909-936. 
Review article covering diets and nutritional supplements, cannabis and cannabinoids (4 pages), acupuncture, chelation, energy healing, and suggestions for how to work with patients interested in incorporating some of these approaches into their care.

Survey of Cannabis Use in Patients with Amyotrophic Lateral Sclerosis
Antmann D, Weydt P, Johnson KL, Jensen MP, Carter GT. Survey of cannabis use in patients with amyotrophic lateral sclerosis. Am J Hosp Palliat Care 2004;21:95-104
Survey of ALS patients done in 2003. Of the 131 respondents, 13 (10%) said they had used marijuana in the past 12 months and three reported daily use. Respondents reported marijuana helped moderately for depression, appetite loss, spasticity, drooling, and pain. None of the cannabis users reported any reduction in difficulties with swallowing and speech or sexual dysfunction.

Updated Tuesday, August 06, 2019 at 11:26AM