Medical Cannabis Review Articles and Reports on Inflammatory Bowel Disease
A Review of Medical Cannabis Studies relating to Chemical Compositions and Dosages for Qualifying Medical Conditions (PDF)
Office of Medical Cannabis.
Summary of clinical trials and prospective observational studies in humans, published in peer-reviewed journals, which focus on medical cannabis formulations consistent with Minnesota’s medical cannabis program.
Information for Health Care Professionals: Cannabis and the cannabinoids (PDF)
Health Canada. February, 2013.
Endocannabinoid system, clinical pharmacology, dosing, potential therapeutic uses (by condition), precautions, warnings, adverse effects, and overdose/toxicity.
Cannabis: The Evidence for Medical Use
Barnes MP, Barnes JC. Report published by Northumberland, Tyne & Wear NHS Foundation Trust, May 2016.
Literature review and discussion of strength of evidence of effectiveness for a wide variety of medical conditions. This report was commissioned by the All Party Parliamentary Group for Drug Policy Reform (UK). The authors note they received no renumeration other than a small grand from the APPG for Drug Policy Reform for their work and that they have no commercial interests in cannabis or cannabis products. The report includes good discussions of the evidence – or lack thereof – for long-term negative effects often ascribed to marijuana use: psychotic disorders, dependence, respiratory system cancer, cognition, amotivational syndrome, and decreased brain volume.
Therapeutic Use of Cannabis in Inflammatory Bowel Disease
Ahmed W, Katz S. Gastroenterology & Hepatology 2016;12:668-679.
Review article. Identifies and discusses the survey and observational studies and the few clinical trials, with discussion of weaknesses of the small clinical trials. Includes assessment of role of endocannabinoid system in IBD. Conclusion of abstract, “Cannabis use should be reserved for symptomatic control in patients with severe IBD refractory to the currently available standard-of-care and complementary and alternative medicines.”
Endocannabinoids in the Gut
DiPatrizio NV. Cannabis and Cannabinoid Research Volume 1:1 2016. DOI: 10.1089/can.2016.0001.
Detailed review of research articles regarding the role of the endocannabinoid system for regulating a variety of gastrointestinal functions, including motility, gut-brain-mediated fat intake and hunger signaling, inflammation and gut permeability, and dynamic interactions with gut microbiota.
Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review
Leinwand KL, Gerich ME, Hoffenberg EJ, Collins CB. Manipulation of the endocannabinoid system in colitis: A comprehensive review. Inflamm Bowel Dis 2017;23:192-199.
Well-written review of components of the endocannabinoid system relevant to the colon and impact of cannabinoids in human diseases.
Cannabis, cannabinoids, and the endocannabinoid system - Is there therapeutic potential for inflammatory bowel disease?
Ambrose T, Simons A. Cannabis, cannabinoids, and the endocannabinoid system – Is there therapeutic potential for inflammatory bowel disease? J Crohns Colitis 2019;30:525-535.
From the article’s abstract: “This review article synthesizes the current literature surrounding the modulation of the endocannabinoid system and administration of exocannabinoids in experimental and human IBD. Findings of clinical surveys and studies of cannabis use in IBD are summarized. Discrepancies in the literature are highlighted together with identifying novel areas of interest.”