Medical Cannabis Review Articles and Reports on Obstructive Sleep Apnea
The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research
A report published by the U.S. National Academies of Sciences, Engineering, and Medicine. 2017.
A rigorous review of relevant scientific research published since 1999, summarizing the current state of evidence regarding what is known about the health impacts of cannabis and cannabis-derived products, including effects related to therapeutic uses of cannabis and potential health risks related to certain cancers, diseases, mental health disorders, and injuries. Sections on evidence of therapeutic effects include: chronic pain, cancer treatment, chemotherapy-induced nausea and vomiting, anorexia and weight loss associated with HIV/AIDS, cancer-associated anorexia-cachexia syndrome, anorexia nervosa, irritable bowel syndrome, epilepsy, spasticity associated with multiple sclerosis or spinal cord injury, Tourette syndrome, amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, dystonia, dementia, glaucoma, traumatic brain injury/intracerebral hemorrhage, substance addiction, anxiety, depression, sleep disorders, posttraumatic stress disorder, and schizophrenia and other psychoses. Chapters summarizing evidence of harms include: cancer, cardiometabolic risk, respiratory disease, immunity, injury and death, prenatal/perinatal/neonatal exposure, psychosocial, mental health, cannabis use problems, and abuse of other substances.
A Review of Medical Cannabis Studies relating to Chemical Compositions and Dosages for Qualifying Medical Conditions (PDF)
Office of Medical Cannabis.
Summary of clinical trials and prospective observational studies in humans, published in peer-reviewed journals, which focus on medical cannabis formulations consistent with Minnesota’s medical cannabis program.
Medical Cannabis and the Treatment of Obstructive Sleep Apnea: An American Academy of Sleep Medicine Position Statement
Ramar K, Rosen IM, Kirsh DB, Chervin RD, et al. Medical cannabis and the treatment of obstructive sleep apnea: An American Academy of Sleep Medicine position statement. J Clin Sleep Med 2018;14:679-681.
The AASM issued this position statement in opposition to use of cannabis or cannabinoids as therapy for obstructive sleep apnea. It reads, in part, “… medical cannabis and/or its synthetic extracts should not be used for the treatment of OSA due to unreliable delivery methods and insufficient evidence of effectiveness, tolerability, and safety.”
Cannabis, cannabinoids, and sleep: A review of the literature
Babson KA, Sottile J, Morabito D, Cannabis, cannabinoids, and sleep: A review of the literature. Curr Psychiatry Rep 2017 Apr;19(4).23. doi: 10.1007/s11920-017-0775-9.
This review article covers the impact of cannabis on sleep; sleep-wake cycle – role of endocannabinoid system and effects of cannabinoids; and cannabinoids and specific sleep disorders – insomnia, obstructive sleep apnea, REM behavior disorder, nightmares, sleep in pain conditions, and daytime sleepiness.