Human Health-Based Water Guidance Table

The Minnesota Department of Health (MDH) develops health-based rules and guidance to evaluate potential human health risks from exposures to chemicals in groundwater. For more information, see: Health-Based Guidance for Water or contact the Health Risk Assessment Unit.

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Key to table entries

Value Type: HRL = Health Risk Limits; HBV = Health-Based Values; and RAA = Risk Assessment Advice. Subscripts either indicate the last two digits of the year the value was developed or that the HRL is based on a US EPA Maximum Contaminant Level (MCL).

Exposure Duration: Acute = one day exposure; Short-term = greater than one day up to 30 days; Subchronic = greater than 30 days up to 10% of a lifetime; Chronic = greater than 10% of a lifetime; and Cancer = zero to 70 years of age

Related links

Other guidance is also available for certain methods and substances, including lead, dioxins, and PAHs.

Information from the water guidance table and a calculator for exposures to multiple chemicals is available for download: MDH Water Guidance and Additivity Calculator (Excel)

Guidance Table

CAS Number Chemical Value Type Exposure
Duration
Value
(µg/L)
Health Endpoint(s)
Find chemicals beginning with:    A - C     D - E     F - M     N - S     T - Z    
83-32-9

Acenaphthene

Toxicological Summary for Acenaphthene (PDF)

Information Sheet: Acenaphthene in Drinking Water (PDF)

HRL93 Chronic 400 Liver system
HBV15
Acute ND --
Short-term ND --
Subchronic 200 Adrenal; Liver system
Chronic 100 Adrenal; Liver system
Cancer N/A --
103-90-2

Acetaminophen

Toxicological Summary for Acetaminophen (PDF)

Information Sheet: Acetaminophen in Drinking Water (PDF)

HRL15 Acute 200 Liver system
Short-term 200 Liver system
Subchronic 200* Liver system
Chronic 200* Liver system
Cancer N/A --
34256-82-1

Acetochlor

Toxicological Summary for Acetochlor (PDF)
     See also degradates:         Acetochlor ESA
        Acetochlor OXA 

HRL09 Acute 40 Developmental
Short-term 40 Developmental
Subchronic 40* Developmental
Chronic 9 Liver system; Male reproductive system; Nervous system; Kidney system; Respiratory system
Cancer NA --
187022-11-3

Acetochlor ESA

Toxicological Summary for Acetochlor ESA (PDF)
     (degradate of Acetochlor)

HRL11 Acute ND --
Short-term 600 Thyroid (E)
Subchronic 600 Thyroid (E)
Chronic 300 Thyroid (E)
Cancer NA --
184992-44-4

Acetochlor OXA

Toxicological Summary for Acetochlor OXA (PDF)
      (degradate of Acetochlor)

HRL11 Acute ND --
Short-term 200 Thyroid (E)
Subchronic 200 Thyroid (E)
Chronic 100 Thyroid (E)
Cancer NA --
67-64-1

Acetone

Toxicological Summary for Acetone (PDF)

HRL11 Acute ND --
Short-term 9,000 Kidney system
Subchronic 8,000 Kidney system; Blood system
Chronic 4,000 Kidney system; Blood system
Cancer NA --
21145-77-7 or 1506-02-1

6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN or Tonalide)

Toxicological Summary for 6-Acetyl-1,12,4,4,7-hexamethyltetraline (PDF)

Information Sheet: AHTN in Drinking Water (PDF)

HRL13  Acute ND --
Short-term 100 Liver system
Subchronic 30 Liver system
Chronic 20 Liver system
Cancer NA --
79-06-1

Acrylamide

Toxicological Summary for Acrylamide (PDF)

Information Sheet: Acrylamide in Drinking Water (PDF)

HRL15  Acute ND --
Short-term 7 Developmental; Male reproductive system; Nervous system
Subchronic 7* Developmental; Male reproductive system; Nervous system
Chronic 7* Developmental; Male reproductive system; Nervous system
Cancer 0.2 Cancer
15972-60-8

Alachlor

Toxicological Summary for Alachlor (PDF)
     See also degradates         Alachlor ESA
        Alachlor OXA

HRL09 Acute ND --
Short-term 200 Kidney system
Subchronic 30 Blood system; Liver system
Chronic 5 Blood system; Liver system
Cancer NA --
142363-53-9



Alachlor ESA

Toxicological Summary for Alachlor ESA (PDF)
     (degradate of Alachlor)

 

RAA15  Acute ND --
Short-term ND --
Subchronic 90 Blood system
Chronic 60 Blood system
Cancer NA --
171262-17-2

Alachlor OXA

Toxicological Summary for Alachlor OXA (PDF)
     (degradate of Alachlor)

RAA15  Acute ND --
Short-term ND --
Subchronic 90 Blood system
Chronic 60 Blood system
Cancer NA --
116-06-3 Aldicarb HRL93 Chronic 1 Nervous system
107-05-1 Allyl chloride (3 chloropropene) HRL94 Chronic 30 Nervous system
120-12-7 Anthracene HRL93 Chronic 2,000  None
7440-36-0 Antimony HRL93 Chronic 6 --
1912-24-9 Atrazine HRLMCL Chronic 3 see USEPA Organic Chemicals table
7440-39-3 Barium HRL93 Chronic 2,000 Cardiovascular system
25057-89-0

Bentazon

Toxicological Summary for Bentazon (PDF)

Information Sheet: Bentazon in Drinking Water (PDF)

HRL15 Acute 400 Developmental; Female reproductive system
Short-term 60 Developmental
Subchronic 50 Blood system
Chronic 30 Thyroid
Cancer NA --
71-43-2

Benzene

Toxicological Summary for Benzene (PDF)

HRL09 Acute 10 Developmental
Short-term 10 Blood system; Immune system
Subchronic 3 Blood system; Immune system
Chronic 3** Blood system; Immune system
Cancer 2 Cancer
50-32-8

Benzo[a]pyrene

Toxicological Summary for Benzo(a)pyrene (PDF)

Information Sheet: Benzo(a)pyrene in Drinking Water (PDF)

 

HBV12  Acute 2 Developmental
Short-term 0.3 Developmental
Subchronic 0.3* Developmental
Chronic 0.3* Developmental
Cancer 0.06 Cancer

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65-85-0 Benzoic acid HRL93 Chronic 30,000  None
7440-41-7 Beryllium HRL93 Cancer 0.08 Cancer
92-52-4 1,1-Biphenyl (Diphenyl) HRL93 Chronic 300 Kidney system
111-44-4 Bis(chloroethyl) ether (BCEE) HRL93 Cancer 0.3 Cancer
542-88-1 Bis(chloromethyl) ether (BCME) HRL93 Cancer 0.002 Cancer
80-05-7

Bisphenol A (BPA)

Toxicological Summary for Bisphenol A (PDF)

Information Sheet: Bisphenol A in Drinking Water (PDF)

HRL15  Acute ND --
Short-term 100 Developmental; Female reproductive system (E); Liver system; Male reproductive system (E); Kidney system; Thyroid (E)
Subchronic 20 Liver system; Kidney system
Chronic 20** Liver system; Kidney system
Cancer NA --
7440-42-8 Boron
RAA08 Chronic 1,000 Developmental
75-27-4 Bromodichloromethane HRL93 Cancer 6 Cancer
75-25-2 Bromoform HRL93 Cancer 40 Cancer
74-83-9 Bromomethane (Methyl bromide) HRL93 Chronic 10 Gastrointestinal system
71-36-3 n-Butanol HRL93 Chronic 700 Nervous system
85-68-7

Butyl benzyl phthalate (BBP)

Toxicological Summary for Butyl benzyl phthalate (PDF)

Information Sheet: Phthalates and Drinking Water (PDF)

HRL15 Acute 100 Developmental (E)
Short-term 100 Developmental (E)
Subchronic 100* Developmental (E)
Chronic 100* Developmental (E)
Cancer NA --
85-70-1 Butylphthalyl butylglycolate (BPBG) HRL93 Chronic 7,000  None
7440-43-9

Cadmium

Toxicological Summary for Cadmium (PDF)

Information sheet: Cadmium and Drinking Water (PDF)

HRL15 Acute 5 Developmental
Short-term 1 Developmental; Nervous system; Renal (kidney) system
Subchronic 1 Developmental; Skeletal
Chronic 0.5 Renal (kidney) system; Skeletal
Cancer NA --
298-46-4

Carbamazepine

Toxicological Summary for Carbamazepine (PDF)

Information Sheet: Carbamazepine in Drinking Water (PDF)

HRL13  Acute 40 Developmental; Nervous system
Short-term 40 Developmental; Blood system; Liver system; Immune system;
Nervous system;
Male reproductive system (E); Female reproductive system (E); Thyroid (E)
Subchronic 40* Developmental; Blood system; Liver system; Immune system; Nervous system; Male reproductive system (E); Female reproductive system (E);Thyroid (E)
Chronic 40* Developmental; Blood system; Liver system; Immune system; Nervous system; Male reproductive system (E); Female reproductive system (E); Thyroid (E)
Cancer NA --
75-15-0 Carbon disulfide HRL93 Chronic 700 Developmental
56-23-5

Carbon tetrachloride

Toxicological Summary for Carbon tetrachloride (PDF)

HRL13 Acute 100 Developmental; Liver system
Short-term 3 Liver system
Subchronic 3* Liver system
Chronic 3* Liver system
Cancer 1 Cancer
133-90-4 Chloramben HRL94 Chronic 100 Liver system
108-90-7 Chlorobenzene HRL93 Chronic 100 Liver system
75-00-3

Chloroethane

Toxicological Summary for Chloroethane (PDF)

RAA09  Acute ND --
Short-term ND --
Subchronic ND --
Chronic ND --
Cancer NA --
67-66-3

Chloroform

Toxicological Summary for Chloroform (PDF)

HRL09 Acute ND --
Short-term 30 Developmental; Liver system; Immune system
Subchronic 30* Developmental; Liver system; Immune system; Male reproductive system
Chronic 30* Developmental; Liver system; Immune system; Male reproductive system
Cancer NA --
95-57-8 2-Chlorophenol HRL93 Chronic 30 Developmental
1897-45-6 Chlorothalonil HRL94 Cancer 30 Cancer
2921-88-2

Chlorpyrifos

Toxicological Summary for Chlorpyrifos (PDF)

Information Sheet: Chlorpyrifos and Drinking Water (PDF)

HBV13  Acute 2 Nervous system
Short-term 0.6 Nervous system
Subchronic 0.6* Nervous system
Chronic 0.6* Nervous system
Cancer NA --
5598-15-2

Chlorpyrifos Oxon (degradate of Chlorpyrifos)

Toxicological Summary for Chlorpyrifos Oxon (PDF)

Information Sheet: Chlorpyrifos and Drinking Water (PDF)

RAA13  Acute 0.9 Nervous system
Short-term 0.4 Nervous system
Subchronic 0.4* Nervous system
Chronic 0.4* Nervous system
Cancer NA --
16065-83-1 Chromium III HRL94 Chronic 20,000  None
18540-29-9 Chromium VI HRL93 Chronic 100  None
210880-92-5, 205510-53-8

Clothianidin

Toxicological Summary for Clothianidin (PDF)

Information Sheet: Clothianidin and Drinking Water (PDF)

HBV16 Acute ND --
Short-term 200 Developmental
Subchronic 200 Developmental
Chronic 200** Developmental
Cancer NA --
98-82-8 Cumene (Isopropyl benzene) HRL93 Chronic 300  None
21725-46-2

Cyanazine

Toxicological Summary for Cyanazine (PDF)

HRL09 Acute 2 Developmental, Female reproductive system
Short-term 2 Developmental, Female reproductive system
Subchronic 2 Liver system; Kidney system
Chronic 1 None
Cancer NA --
57-12-5 Cyanide, free HRL93 Chronic 100 Nervous system; Thyroid (E)

Go to > top.

93413-62-8, 386750-22-7, 300827-87-6, 93414-04-1

Desvenlafaxine

Toxicological Summary for Desvenlafaxine (PDF)

Information Sheet: Venlafaxine and Desvenlafaxine and Drinking Water (PDF)

HBV15  Acute ND --
Short-term 20 Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
Subchronic 20* Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
Chronic 20* Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
Cancer NA --
124-48-1 Dibromochloromethane HRL93 Chronic 10 Liver system
106-93-4 1,2-Dibromoethane (ethylene dibromide, EDB) HRL93 Cancer 0.004 Cancer
84-74-2

Dibutyl phthalate (DBP)

Toxicological Summary for Dibutyl phthalate (PDF)

Information Sheet: Phthalates and Drinking Water (PDF)

HRL15 Acute 20 Developmental (E)
Short-term 20 Developmental (E)
Subchronic 20* Developmental (E)
Chronic 20* Developmental (E)
Cancer NA --
1918-00-9 Dicamba HRL93 Chronic 200 Developmental
95-50-1 1,2-Dichlorobenzene HRL93 Chronic 600 Liver system
106-46-7 1,4-Dichlorobenzene (para) HRL94 Cancer 10 Cancer
91-94-1 3,3'-Dichlorobenzidine HRL93 Cancer 0.8 Cancer
75-71-8

Dichlorodifluoromethane

Toxicological Summary for Dichlorodifluoromethane
(PDFs)

HRL11 Acute ND --
Short-term ND --
Subchronic ND --
Chronic 700 None
Cancer NA --
72-54-8 p,p'-Dichlorodiphenyldichloroethane (DDD) HRL93 Cancer 1 Cancer
72-55-9 p,p'-Dichlorodiphenyldichloroethylene (DDE) HRL93 Cancer 1 Cancer
50-29-3 p,p'-Dichlorodiphenyltrichloroethane (DDT) HRL93 Cancer 1 Cancer
75-34-3

1,1-Dichloroethane

Toxicological Summary for 1,1-Dichloroethane (PDF)

RAA15 Acute ND --
Short-term 400 Nervous system
Subchronic 400* Nervous system
Chronic 80 Nervous system
Cancer NA --
107-06-2

1,2-Dichloroethane

Toxicological Summary for 1,2-Dichloroethane (PDF)

HRL13  Acute ND --
Short-term 200 Liver system
Subchronic 200* Liver system
Chronic 60 Kidney system; Liver system
Cancer 1 Cancer
156-59-2

cis-1,2-Dichloroethene

Toxicological Summary for cis-1,2-Dichloroethene (PDF)

HRL09 Acute ND --
Short-term 70 Blood system
Subchronic 70* Blood system
Chronic 50 Blood system
Cancer NA --

cis-1,2-Dichloroethene

Toxicological Summary for cis-1,2-Dichloroethene (PDF)

Information sheet: cis-1,2-Dichloroethene and Drinking Water (PDF)

HBV14  Acute ND --
Short-term 20 Liver system
Subchronic 10 Kidney system
Chronic 6 Kidney system
Cancer NA --
156-60-5

trans-1,2-Dichloroethene

Toxicological Summary for trans-1,2-Dichloroethene (PDF)

HRL13  Acute ND --
Short-term ND --
Subchronic 200 Immune system
Chronic 40 Immune system
Cancer NA --
75-35-4

1,1-Dichloroethylene (Vinylidene chloride)

Toxicological Summary for 1,1-Dichloroethylene (Vinylidene chloride) (PDF)

HRL11 Acute ND --
Short-term ND --
Subchronic 200 Liver system
Chronic 200 Liver system
Cancer NA --
75-43-4

Dichlorofluoromethane (DCFM)

Toxicological Summary for Dichlorofluoromethane (PDF)

Information sheet: Dichlorofluoromethane and Drinking Water (PDF)

RAA15 Acute ND --
Short-term 30 Immune system; Liver system; Developmental
Subchronic 30* Developmental; Liver system; Immune system; Male reproductive system
Chronic 30* Developmental; Liver system; Immune system; Male reproductive system
Cancer NA --
75-09-2 Dichloromethane (Methylene chloride) HRLMCL Chronic 5 see USEPA Organic Chemicals table
120-83-2 2,4-Dichlorophenol HRL93 Chronic 20 Immune system
94-75-7 2,4-Dichlorophenoxyacetic acid (2,4-D) HRL93 Chronic 70 Blood system; Liver system; Kidney system
78-87-5 1,2-Dichloropropane HRL94 Cancer 5 Cancer
542-75-6 1,3-Dichloropropene HRL94 Cancer 2 Cancer
60-57-1

Dieldrin

Toxicological Summary for Dieldrin (PDF)

HRL09 Acute 0.2 Developmental
Short-term 0.2 Developmental; Immune system; Nervous system
Subchronic 0.2* Developmental; Immune system; Nervous system
Chronic 0.2 Liver system; Nervous system
Cancer 0.006 Cancer
134-62-3

N,N-Diethyl-meta-toluamide (DEET)

Toxicological Summary for N,N-Diethyl-meta-toluamide (DEET) (PDF)

Information Sheet: DEET in Drinking Water (PDF)

HRL13  Acute ND --
Short-term 200 Developmental; Nervous system
Subchronic 200* Developmental; Nervous system
Chronic 200* Developmental; Nervous system
Cancer NA --

Go to > top.

117-81-7

Di(2-ethylhexyl)phthalate (DEHP)

Toxicological Summary for Di(2-ethylhexyl) phthalate (PDF)

Information Sheet: Phthalates and Drinking Water (PDF)

HRL15 Acute 20 Developmental (E); Male reproductive system (E)
Short-term 20 Developmental (E); Male reproductive system (E)
Subchronic 20* Developmental (E); Male reproductive system (E)
Chronic 20* Developmental (E); Male reproductive system (E)
Cancer 7 Cancer
84-66-2 Diethyl phthalate HRL93 Chronic 6,000  None
87674-68-8
163515-14-8

Dimethenamid & Dimethenamid-P

Toxicological Summary for Dimethenamid & Dimethenamid-P (PDF)

Information Sheet: Dimethenamid and Drinking Water (PDF)

See also degradates: Dimethenamid ESA & Dimethenamid OXA (PDF)

HRL15 

Acute ND --
Short-term 600 Developmental; Liver system; Nervous system; Female reproductive system
Subchronic 600* Developmental; Liver system; Nervous system; Female reproductive system
Chronic 300 Liver system
Cancer NA --
205939-58-8 not found

Dimethenamid ESA
Dimethenamid OXA

Toxicological Summary for Dimethenamid Degradates: ESA and OXA (PDF)

Information Sheet: Dimethenamid and Drinking Water (PDF)

RAA13

Acute ND --
Short-term 600 Developmental; Liver system; Nervous system; Female reproductive system
Subchronic 600 Developmental; Liver system
Chronic 300 Liver system
Cancer NA --
105-67-9 2,4-Dimethylphenol HRL93 Chronic 100 Blood system; Nervous system
131-11-3 Dimethylphthalate HRL94 Chronic 70,000 Kidney system
51-28-5 2,4-Dinitrophenol HRL94 Chronic 10 Eyes
123-91-1

1,4-Dioxane

Toxicological Summary for 1,4-Dioxane (PDF)  

Information Sheet: 1,4-Dioxane in Drinking Water (PDF)

HRL13  Acute ND --
Short-term ND --
Subchronic 300 Liver system; Kidney system; Respiratory system
Chronic 100 Liver system; Kidney system; Respiratory system
Cancer 1 Cancer
298-04-4 Disulfoton HRL94 Chronic 0.3 Nervous system
100-41-4

Ethylbenzene

Toxicological Summary for Ethylbenzene (PDF)

HRL11 Acute ND --
Short-term 50 Liver system; Kidney system
Subchronic 50* Liver system; Kidney system
Chronic 50* Liver system; Kidney system
Cancer NA --
759-94-4

S-Ethyl-N,N-dipropylthiocarbamate (EPTC)

Toxicological Summary for S-Ethyl-N,N-dipropythiocarbamate (PDF)

Information Sheet: S-Ethyl-N,N-dipropythiocarbamate (EPTC) and Drinking Water (PDF)

HRL93 Chronic 200 Cardiovascular system; Nervous system
HBV15 Acute 300 Nervous system
Short-term 300 Developmental; Female reproductive system; Nervous system
Subchronic 90 Cardiovascular system
Chronic 40 Cardiovascular system
Cancer NA --
60-29-7

Ethyl ether

Toxicological Summary for Ethyl ether (PDF)

RAA10 Acute ND --
Short-term ND --
Subchronic 1000 Liver system; Kidney system
Chronic 200 Liver system; Kidney system
Cancer NA --
107-21-1

Ethylene glycol

Toxicological Summary for Ethylene glycol (PDF)

HRL11 Acute 4,000 Developmental
Short-term 4,000 Developmental
Subchronic 2,000 Developmental; Kidney system
Chronic 2,000 Developmental; Kidney system
Cancer NA --
206-44-0

Fluoranthene

Toxicological Summary for Fluoranthene (PDF)

Information Sheet: Fluoranthene in Drinking Water (PDF)

HRL93 Chronic 300 Liver system; Kidney system
HBV15 Acute ND --
Short-term ND --
Subchronic 100 Liver system; Kidney system
Chronic 70 Liver system; Kidney system
Cancer N/A see Guidance for Evaluating the Cancer Potency of PAH Mixtures (PDF)
86-73-7 Fluorene (9H-Fluorene) HRL93 Chronic 300 Blood system
50-00-0 Formaldehyde HRL94 Chronic 1,000 Gastrointestinal system
76-44-8 Heptachlor HRL93 Cancer 0.08 Cancer
1024-57-3 Heptachlor epoxide HRL93 Cancer 0.04 Cancer
118-74-1 Hexachlorobenzene HRL93 Cancer 0.2 Cancer
87-68-3 Hexachlorobutadiene HRL93 Chronic 1 Kidney system
110-54-3 Hexane (n-hexane) HRL94 Chronic 400 Nervous system
78-83-1

Isobutanol
Toxicological Summary for Isobutanol (PDF)

Information Sheet: Isobutanol and Drinking Water (PDF)

HBV14 Acute ND --
Short-term ND --
Subchronic 600 Male reproductive system
Chronic 300 Male reproductive system
Cancer NA --
78-59-1 Isophorone HRL93 Chronic 100 Kidney system
330-55-2 Linuron HRL93 Chronic 1 Blood system
7439-96-5

Manganese

Toxicological Summary for Manganese (PDF)

Tiered Health Based Guidance for Water

Information sheet: Manganese in Drinking Water (PDF)

HRL93*** Chronic 100 Nervous system
RAA12  Infant 100 Nervous system
RAA12  Child/Adult 300 Nervous system
67-56-1 Methanol HRL94 Chronic 3,000 Liver system; Nervous system
94-74-6 2-Methyl-4-chlorophenoxyacetic acid (MCPA) HRL93 Chronic 3 Liver system; Kidney system
78-93-3 Methyl ethyl ketone (MEK, 2-butanone) HRL94 Chronic 4,000 Developmental
108-10-1 Methyl isobutyl ketone (MIBK) HRL94 Chronic 300 Liver system; Kidney system
1634-04-4

Methyl tert-butyl ether (MTBE)

Toxicological Summary for Methyl tert-butyl ether (MTBE) (PDF)

Information Sheet for Methyl tert-butyl ether (MTBE) and Drinking Water (PDF)

RAA13  Acute ND --
Short-term 700 Liver system; Nervous system; Kidney system
Subchronic 700* Liver system; Nervous system; Kidney system
Chronic 700* Liver system; Nervous system; Kidney system
Cancer 60 Cancer
91-57-6

2-Methylnaphthalene

Toxicological Summary for 2-Methylnaphthalene (PDF)

Information Sheet: 2-Methylnaphthalene and Drinking Water (PDF)

RAA13 Acute ND --
Short-term ND --
Subchronic ND --
Chronic 8 Respiratory system
Cancer ND --
95-48-7 2-Methylphenol (o-cresol) HRL93 Chronic 30 Nervous system
108-39-4 3-Methylphenol (m-cresol) HRL93 Chronic 30 Nervous system
106-44-5 4-Methylphenol (p-cresol) HRL94 Chronic 3  None
51218-45-2;
87392-12-9

Metolachlor and s-Metolachlor

Toxicological Summary for Metolachlor and s-Metolachlor (PDF)
     See also degradates         Metolachlor ESA
        Metolachlor OXA

HRL11 Acute 400 Developmental
Short-term 400 Developmental
Subchronic 300 None
Chronic 300** None
Cancer NA --
171118-09-5

Metolachlor ESA

Toxicological Summary for Metolachlor ESA (PDF)
     (degradate of Metolachlor)

HRL11 Acute ND --
Short-term ND --
Subchronic 4,000 Liver system
Chronic 800 Liver system
Cancer NA --
152019-73-3

Metolachlor OXA

Toxicological Summary for Metolachlor OXA (PDF)
     (degradate of Metolachlor)

HRL11 Acute ND --
Short-term 3,000 None
Subchronic 3,000* None
Chronic 800 None
Cancer NA --
21087-64-9

Metribuzin

Toxicological Summary for Metribuzin (PDF)

See also degradates: Metribuzin DA, DK, and DADK (PDF)

HRL13  Acute 30 Developmental; Nervous system
Short-term 10 Thyroid (E)
Subchronic 10* Thyroid (E)
Chronic 10* Thyroid (E)
Cancer NA --
35045-02-4;
56507-37-0;
52236-30-3

Metribuzin DA, DK, and DADK

Toxicological Summary for Metribuzin Degradates DA, DK, and DADK (PDF)

Information Sheet: Metribuzin Degradates in Drinking Water (PDF)

RAA12 Acute 30 Developmental; Nervous system
Short-term 10 Thyroid (E)
Subchronic 10* Thyroid (E)
Chronic 10* Thyroid (E)
Cancer NA --

77238-39-2; 101043-37-2

Microcystin

Toxicological Summary for Microcystin (PDF)

Information Sheet: Microcystin-LR in Drinking Water (PDF)

HBV15 Acute NA --
Short-term 0.1 Liver System
Subchronic 0.1* Liver System
Chronic 0.1 Liver System
Cancer NA --

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91-20-3

Naphthalene

Toxicological Summary for Naphthalene (PDF)

HRL13  Acute 70 Nervous system
Short-term 70 Nervous system
Subchronic 70* Nervous system
Chronic 70 Nervous system, Spleen
Cancer NA --
7440-02-0 Nickel, soluble salts HRL93 Chronic 100  None
14797-55-8 Nitrate (as nitrogen) HRLMCL Acute 10,000 see USEPA Inorganic Chemicals table
86-30-6 N-Nitrosodiphenylamine HRL93 Cancer 70 Cancer
84852-15-3

Nonylphenol

Toxicological Summary for p-Nonylphenol, branched isomers (PDF)

Information Sheet: Nonylphenols and Drinking Water (PDF)

HBV15 Acute ND --
Short-term 100 Developmental; Female reproductive system
Subchronic 40 Kidney system
Chronic 20 Kidney system
Cancer NA --
140-66-9

4-tert-Octylphenol

Toxicological Summary for 4-tert-Octylphenol (PDF)

Information Sheet: Octylphenol and Drinking Water (PDF)

HBV15 Acute ND --
Short-term 100 Developmental
Subchronic 100* Developmental
Chronic 100* Developmental
Cancer NA --
87-86-5

Pentachlorophenol (PCP)

Toxicological Summary for Pentachlorophenol (PCP) (PDF)

Information Sheet: Pentachlorophenol and Drinking Water (PDF)

HRL15  Acute 7 Developmental; Thyroid (E)
Short-term 7 Developmental (E); Thyroid (E)
Subchronic 7* Developmental (E); Liver system; Immune system; Male Reproductive system; Thyroid (E)
Chronic 7* Developmental (E); Liver system; Immune system; Male Reproductive system; Thyroid (E)
Cancer 0.3 Cancer
375-73-5

Perfluorobutane sulfonate (PFBS)

Toxicological Summary for Perfluorobutane sulfonate (PFBS) (PDF)

HRL11 Acute ND --
Short-term ND --
Subchronic 9 Blood system; Liver system;Kidney system
Chronic 7 Blood system; Liver system;Kidney system
Cancer NA --
375-22-4

Perfluorobutyrate (PFBA)

Toxicological Summary for Perfluorobutyrate (PFBA) (PDF)

HRL11 Acute ND --
Short-term 7 Liver system; Thyroid (E)
Subchronic 7* Liver system; Thyroid (E)
Chronic 7* Liver system; Thyroid (E)
Cancer NA --
355-46-4

Perfluorohexane sulfonate (PFHxS)

Toxicological Summary for Perfluorohexane sulfonate (PFHxS) (PDF)

RAA09 Acute ND --
Short-term ND --
Subchronic ND --
Chronic ND --
Cancer NA --
335-67-1;
335-66-0;
3825-26-1;
2395-00-8;
335-93-3;
335-95-5

Perfluorooctanoic Acid (PFOA) and Salts

Toxicological Summary for Perfluorooctanoic Acid (PFOA) and Salts (PDF)

HRL09 Acute ND --
Short-term ND --
Subchronic ND --
Chronic 0.3 Development effects; Liver system; Immune system
Cancer NA --
1763-23-1;
29081-56-9;
70225-14-8;
2795-39-3;
29457-72-5

Perfluorooctane Sulfonate (PFOS) and Salts

Toxicological Summary for Perfluorooctane Sulfonate (PFOS) and Salts (PDF)

HRL09 Acute ND --
Short-term ND --
Subchronic ND --
Chronic 0.3 Developmental effects; Liver system; Thyroid (E)
Cancer NA --
108-95-2 Phenol HRL93 Chronic 4,000 Developmental
1918-02-1 Picloram HRL93 Chronic 500 Liver system
1336-36-3 Polychlorinated biphenyls (PCBs) HRL94 Cancer 0.04 Cancer
1610-18-0 Prometon HRL93 Chronic 100  None
1918-16-7 Propachlor HRL93 Chronic 90  None
175013-18-0

Pyraclostrobin

Toxicological Summary for Pyraclostrobin (PDF)

Information Sheet: Pyraclostrobin in Drinking Water (PDF)

HBV11 Acute 300 Developmental; Female Reproductive system
Short-term 100 Developmental; Female Reproductive system; Gastrointestinal system; Spleen
Subchronic 100 Developmental; Female Reproductive system; Gastrointestinal system; Blood system; Liver system; Immune system; Spleen
Chronic 100** Developmental; Female Reproductive system; Gastrointestinal system; Blood system; Liver system; Immune system; Spleen
Cancer NA --
129-00-0

Pyrene

Toxicological Summary for Pyrene (PDF)

Information Sheet: Pyrene in Drinking Water (PDF)

HRL93 Chronic 200 Kidney system
HBV15  Acute ND --
Short-term ND --
Subchronic 90 Kidney system
Chronic 50 Kidney system
Cancer N/A --
7782-49-2 Selenium HRL93 Chronic 30  None
7440-22-4 Silver HRL93 Chronic 30  None
122-34-9 Simazine HRLMCL Chronic 4 see USEPA Organic Chemicals table
57-68-1

Sulfamethazine

Toxicological Summary for Sulfamethazine (PDF)

Information Sheet: Sulfonamide Antibiotics and Drinking Water (PDF)

HRL15  Acute ND --
Short-term 100 Thyroid
Subchronic 100* Thyroid
Chronic 100* Thyroid
Cancer NA --
723-46-6

Sulfamethoxazole

Toxicological Summary for Sulfamethoxazole (PDF)

Information Sheet: Sulfonamide Antibiotics and Drinking Water (PDF)

RAA13  Acute ND --
Short-term 100 Thyroid
Subchronic 100* Thyroid
Chronic 100* Thyroid
Cancer NA --
630-20-6 1,1,1,2-Tetrachloroethane HRL93 Chronic 70 Kidney system; Liver system
79-34-5 1,1,2,2-Tetrachloroethane HRL94 Cancer 2 Cancer
127-18-4

Tetrachloroethylene (PERC or PCE)

Toxicological Summary for Tetrachloroethylene (PDF)

Information Sheet: Tetrachloroethylene (PCE) and Drinking Water (PDF)

HRLMCL Chronic 5 see USEPA Organic Chemicals table
HBV14  Acute ND --
Short-term ND --
Subchronic 7 Nervous system
Chronic 7** Nervous system
Cancer 4 Cancer

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7440-28-0 Thallium salts HRL94 Chronic 0.6 Liver system
7440-31-5 Tin HRL94 Chronic 4,000 Liver system; Kidney system
108-88-3

Toluene

Toxicological Summary for Toluene (PDF)

HRL11 Acute ND --
Short-term 200 Immune system; Nervous system
Subchronic 200* Immune system; Nervous system
Chronic 200* Immune system; Nervous system
Cancer NA --
8001-35-2 Toxaphene HRL93 Cancer 0.3 Cancer
120-82-1

1,2,4-Trichlorobenzene

Toxicological Summary for 1,2,4-Trichlorobenzene (PDF)

HRL13
Acute ND --
Short-term 100 Liver system; Adrenal (E); Blood system
Subchronic 100* Liver system; Adrenal (E); Blood system
Chronic 100 Liver system; Adrenal (E); Kidney system
Cancer 4 Cancer
108-70-3

1,3,5-Trichlorobenzene

Toxicological Summary for 1,3,5-Trichlorobenzene (PDF)

RAA12 Acute ND --
Short-term 100 Liver system; Adrenal (E); Blood System
Subchronic 100* Liver system; Adrenal (E); Blood system
Chronic 100 Liver system; Adrenal (E); Kidney system
Cancer 4 Cancer
71-55-6

1,1,1-Trichloroethane

Toxicological Summary for 1,1,1-Trichloroethane (PDF)

HRL09 Acute ND --
Short-term ND --
Subchronic 20,000 Liver system; Male reproductive system
Chronic 9,000 Liver system; Male reproductive system
Cancer NA --
79-00-5 1,1,2-Trichloroethane HRL93 Chronic 3 Immune system
79-01-6

1,1,2-Trichloroethylene (TCE)

Toxicological Summary for 1,1,2-Trichloroethylene (TCE) (PDF)

Technical and Application Information

Information Sheet: Trichloroethylene (TCE) and Drinking Water (PDF)

HRL15  Acute ND --
Short-term 0.4 Developmental, Immune
Subchronic 0.4 Developmental, Immune
Chronic 0.4** Developmental, Immune
Cancer 2 Cancer
75-69-4 Trichlorofluoromethane HRL93 Chronic 2,000 None
88-06-2 2,4,6-Trichlorophenol HRL93 Cancer 30 Cancer
93-76-5 2,4,5-Trichlorophenoxyacetic acid HRL93 Chronic 70 Developmental; Blood system
93-72-1 2-(2,4,5-Trichlorophenoxy) propionic acid HRLMCL Chronic 50 see USEPA Organic Chemicals table
96-18-4

1,2,3-Trichloropropane

Toxicological Summary for 1,2,3-Trichloropropane (PDF)

Information Sheet: 1,2,3-TCP in Drinking Water (PDF)

HRL13 Acute 7 Developmental
Short-term 7 Developmental
Subchronic 7* Developmental
Chronic 7* Developmental
Cancer 0.003 Cancer
76-13-1 1,1,2-Trichloro-1,2,2-trifluoroethane HRL93 Chronic 200,000  None
101-20-2

Triclocarban

Toxicological Summary for Triclocarban (PDF)

Information Sheet: Triclocarban and Drinking Water (PDF)

RAA13 Acute ND --
Short-term ND --
Subchronic ND --
Chronic 100 Blood system; Liver system; Male reproductive system; Kidney system
Cancer NA --
3380-34-5

Triclosan

Toxicological Summary for Triclosan (PDF)

Information Sheet: Triclosan and Drinking Water (PDF)

HRL15 Acute ND --
Short-term 50 Developmental; Liver system; Thyroid (E); Female Reproductive system (E)
Subchronic 50* Developmental; Liver system; Thyroid (E); Female Reproductive system (E)
Chronic 50* Developmental; Liver system; Thyroid (E); Female Reproductive system (E)
Cancer NA --
95-63-6

1,2,4-Trimethylbenzene

Toxicological Summary for 1,2,4-Trimethylbenzene (PDF)

RAA10  Acute ND --
Short-term 100 Liver system
Subchronic 100* Liver system
Chronic 100* Liver system
Cancer NA --
108-67-8

1,3,5-Trimethylbenzene

Toxicological Summary for 1,3,5-Trimethylbenzene (PDF)

HRL09 Acute ND --
Short-term 100 Liver system
Subchronic 100* Liver system
Chronic 100* Liver system
Cancer NA --
99-35-4 1,3,5-Trinitrobenzene HRL93 Chronic 0.3  None
115-96-8

Tris(2-chloroethyl)phosphate (TCEP)

Toxicological Summary for Tris(2-chloroethyl)phosphate (PDF)

Information Sheet: TCEP in Drinking Water (PDF)

HRL13 Acute ND --
Short-term 300 Developmental, Nervous system, Kidney system
Subchronic 200 Kidney system
Chronic 200** Kidney system
Cancer 5 Cancer
13674-87-8

Tris(1,3-dichloroisopropyl)phosphate (TDCPP)

Toxicological Summary for Tris(1,3-dichloroisopropyl)phosphate (PDF)

Information Sheet: TDCPP and Drinking Water (PDF)

HBV13  Acute ND --
Short-term ND --
Subchronic 20 Liver system; kidney system
Chronic 9 Kidney system; Male reproductive system
Cancer 0.8 Cancer
7440-62-2 Vanadium HRL94 Chronic 50  None
93413-69-5, 99300-78-4

Venlafaxine

Toxicological Summary for Venlafaxine (PDF)

Information Sheet: Venlafaxine and Desvenlafaxine and Drinking Water (PDF)

HBV15  Acute ND --
Short-term 10 Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
Subchronic 10* Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
Chronic 10* Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E)
Cancer NA --
75-01-4

Vinyl Chloride

Toxicological Summary for Vinyl Chloride (PDF)

HRL09 Acute ND --
Short-term ND --
Subchronic 80 Liver system
Chronic 10 Liver system
Cancer 0.2 Cancer
1330-20-7

Xylenes

Toxicological Summary for Xylenes
(mixture of isomers, o, m, p) (PDF)

HRL11 Acute 800 Nervous system
Short-term 300 Nervous system
Subchronic 300* Kidney system; Nervous system
Chronic 300* Kidney system; Nervous system
Cancer NA --
7440-66-6 Zinc HRL94 Chronic 2,000  None
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NA - Not Applicable
ND - Not derived due to insufficient information
None - Nonspecific effects that could not be attributed to an organ system
(E) = Endocrine mediated effect on the specified target organ

*Set at short-term value
**Set at subchronic value
***Dual guidance applies: See Dual Guidance for Drinking Water


For more information about this page, please contact the Environmental Health Division: health.risk@state.mn.us

Updated Thursday, May 12, 2016 at 02:35PM