Streptococcus pneumoniae Invasive Disease, 2018: DCN - Minnesota Dept. of Health

Streptococcus pneumoniae Invasive Disease, 2018

In 2018, 478 (8.6 per 100,000) cases of invasive pneumococcal disease (IPD) were reported. By age group, annual incidence rates per 100,000 were 7.9 cases among children aged ≤5 years, 2.7 cases among children and adults aged 5-39 years, 9.0 cases among adults 40-64 years, and 25.6 cases among adults aged ≥65 years.

Pneumonia occurred most frequently (55% of infections), followed by bacteremia without another focus of infection (15%), septic shock (12%), and meningitis (6%). Forty-six (10%) cases died. Health histories were available for all 46 deaths; of these, 43 had an underlying health condition reported. The conditions most frequently reported were current tobacco smoker (12), emphysema/ chronic obstructive pulmonary disease (11), cardiac failure (10), chronic kidney disease (10), diabetes (8), current alcohol abuse (8), and obesity (8).

In 1999, the year before the pediatric pneumococcal conjugate vaccine (Prevnar [PCV-7]) was licensed; the rate of IPD among children <5 years of age in the metropolitan area was 111.7 cases/100,000. Over the years 2000-2002 there was a major downward trend in incidence in this age group (Figure 6). Rates in each of the subsequent 8 years were level or somewhat higher. Based on the distribution of serotypes among isolates from these cases, this increase was limited to disease caused by non- vaccine serotypes (i.e. serotypes other than the 7 included in PCV-7) (Figure 6).

In March 2010, the U.S. Food and Drug Administration approved a 13-valent pediatric pneumococcal conjugate vaccine (PCV-13 [Prevnar 13]) which replaced PCV-7. This vaccine provides protection against the same serotypes in PCV-7, plus 6 additional serotypes (serotypes 1, 3, 5, 6A, 7F, and 19A). From 2007 to 2010, the majority of IPD cases among children <5 years of age was caused by the 6 new serotypes included in PCV-13 (Figure 6). Since 2011, the majority of IPD cases among children <5 years of age has been caused by serotypes not included in PCV-13. In 2018, 18% of cases with isolates available for testing were caused by 6 of the PCV- 13-included serotypes: 3 (13%), 19A (2%), 19F (2%), 7F (<1%), 6A (<1%), and 4 (<1%).

In August 2014, the Advisory Committee on Immunization Practices (ACIP) recommended that all adults ≥65 years receive 1 dose of PCV- 13 followed by 1 dose of 23-valent pneumococcal polysaccharide vaccine 6 to 12 months later. Among adults ≥65 years, 14% of cases in 2018 had PCV-13 serotypes.

Of the 452 isolates submitted for 2018 cases, 72 (16%) isolates were resistant to penicillin using meningitis breakpoints. Using non-meningitis breakpoints, 4 (<1%) of 452 isolates were resistant to penicillin. (Note: CLSI penicillin breakpoints changed in 2008).

Invasive pneumococcal disease incidence among children less than 5 years of age by year and serotype group

Updated Monday, 16-Sep-2019 11:18:25 CDT