Provider Guidance and Resources

• MDH Long COVID Guiding Council: Updates from the Field
  • Low Dose Naltrexone for Treatment of Long COVID (PDF): This update summarizes emerging evidence on Low Dose Naltrexone as a potentially effective treatment option for patients with long COVID. Published January 2025.
  • Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Informational Tool for Primary Care Providers (PDF): This tool provides primary care providers with guidance on diagnosing and managing Long COVID patients who present with symptoms consistent with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), including practical tips to support accurate diagnosis, appropriate coding, symptom management, and patient care. Published January 2025.
  • Paxlovid for Prevention of Long COVID (PDF): This update examines the limited literature on the role of Paxlovid in preventing long COVID, identifying and evaluating outcomes from eight observational studies. Updated July 2024.
• Multidisciplinary Collaborative Guidance on the Assessment and Treatment of Patients with Long COVID: A Compendium Statement (PDF)
  A comprehensive collection of updated guidance and evidence-based recommendations from the American Academy of Physical Medicine and Rehabilitation (AAPM&R) Multidisciplinary PASC Collaborative. Designed to support primary care physicians and other healthcare providers in assessing and managing the diverse symptoms of Long COVID. Published April 2025.
• CDC: Clinical Overview of Long COVID 
  Information on assessment and testing, management and follow-up care, documentation, public health recommendations, and more. Includes an extensive list of references.
• American College of Physicians (ACP): Long COVID: Assessment, Diagnosis, and Management of Symptoms 
  Clinical resources and education for evaluating and managing adults experiencing Long COVID symptoms.
• The American Academy of Family Physicians (AAFP): Supporting Family Physicians and Long COVID Patients 
  Overview of Long COVID for family physicians, including definitions, symptoms, clinical guidance, and evidence-based resources.
• Long COVID ECHO Series for Health Care Providers
  The Minnesota Academy of Family Physicians partnered with Stratis Health and the MDH Long COVID Guiding Council on a three-session ECHO focusing on long COVID. Sessions are available to watch on demand (no CME credit for viewing recordings). Published May/June 2024.
• Project ECHO: Long COVID and Fatiguing Illness Recovery Program
  Monthly learning series, resource library, and quarterly short course for providers who care for patients with post-COVID conditions.
• University of California Health: Long COVID/PASC Education
  Free CME credits available (AMA PRA Category 1). Short videos for providers. Topics include evaluation in primary care settings, pediatrics, health disparities, post-ICU complications, psychiatry/behavioral health, emergency medicine, and more. Published November 2022-August 2023.
• Mayo Clinic Proceedings: Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (PDF)
  Concise review for clinicians that describes a generalist approach to ME/CFS (common in long COVID), including diagnosis, evaluation, and management strategies. Published November 2023.
• CDC: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Resources for Healthcare Providers
  Guidance on presentation, diagnosis, clinical care, and more. Long COVID may present as ME/CFS and benefit from similar management.
• MEAction: For Clinicians: Pacing and Management Guide for ME/CFS and Long COVID (PDF)
  A brief guide from ME/CFS patient-advocates and the Patient-Led Research Collaborative.
• U.S. Department of Health and Human Services (HHS): Health+ Long COVID: Human-Centered Design Report (PDF)
  Framework and recommendations, including a map of the "ideal" versus "actual" treatment journey and patient-identified pain points. Published November 2022.
• U.S. Department of Veterans Affairs: Whole Health System Approach to Long COVID (PDF)
  A comprehensive guide from the Patient-Aligned Care Team. Includes quick guides. Published August 2022.
• AAPM&R: Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of post-acute sequelae of SARS-CoV-2 infection (PASC) in children and adolescents
  This consensus guidance outlines pediatric-specific approaches to identifying, assessing, and managing long COVID in children and adolescents. Published September 2022.
• Substance Abuse and Mental Health Services Administration (SAMHSA): Identification and Management of Mental Health Symptoms and Conditions Associated with Long COVID (PDF)
  Includes recommendations for assessments and therapeutic intervention strategies. Published June 2023.