Human Health-Based Water Guidance Table
The Minnesota Department of Health (MDH) develops health-based rules and guidance to evaluate potential human health risks from exposures to chemicals in groundwater. For more information, see: Guidance Values and Standards for Contaminants in Drinking Water or contact the Health Risk Assessment Unit.
Key to table entries
Value Type: HRL = Health Risk Limits; HBV = Health-Based Values; and RAA = Risk Assessment Advice. Subscripts either indicate the last two digits of the year the value was developed or that the HRL is based on a US EPA Maximum Contaminant Level (MCL).
Exposure Duration: Acute = one day exposure; Short-term = greater than one day up to 30 days; Subchronic = greater than 30 days up to 10% of a lifetime; Chronic = greater than 10% of a lifetime; and Cancer = zero to 70 years of age
Related links
Other Minnesota Guidance is also available for certain methods and substances, including lead, dioxins, PAHs, Total Petroleum Hydrocarbon (TPH), as well as rapid assessment values for pesticides and pharmaceuticals.
A Comparison of State Water Guidance and Federal Drinking Water Standards is also available.
When multiple substances are present MDH risk assessment methods require evaluation of the potential risk from the combined exposure. Information from the water guidance table below and a calculator for exposures to multiple chemicals is available for download:
MDH Water Guidance and Additivity Calculator (Excel).
Guidance Table
| CAS Number | Chemical | Value Type | Exposure Duration |
Value (µg/L) |
Health Endpoint(s) |
|---|---|---|---|---|---|
| Find chemicals beginning with: A - C D - E F - M N - S T - Z | |||||
| 83-32-9 | Acenaphthene Toxicological Summary for Acenaphthene (PDF) Information Sheet: Acenaphthene in Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 200 | Adrenal; Liver system | |||
| Chronic | 100 | Adrenal; Liver system | |||
| Cancer | NA | -- | |||
| 103-90-2 | Acetaminophen Toxicological Summary for Acetaminophen (PDF) Information Sheet: Acetaminophen in Drinking Water (PDF) |
HRL15 | Acute | 200 | Liver system |
| Short-term | 200 | Liver system | |||
| Subchronic | 200* | Liver system | |||
| Chronic | 200* | Liver system | |||
| Cancer | NA | -- | |||
| 34256-82-1 |
Acetochlor Toxicological Summary for Acetochlor (PDF) See also degradates: Acetochlor ESA Acetochlor OXA Information Sheet: Acetochlor and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 30 | Developmental; Liver system; Thyroid (E) | |||
| Subchronic | 30 | Liver system; Male reproductive system; Nervous system; Kidney system | |||
| Chronic | 20 | Liver system; Male reproductive system; Nervous system; Kidney system; Respiratory system | |||
| Cancer | NA | -- | |||
| 187022-11-3 | Acetochlor ESA (degradate of Acetochlor) Toxicological Summary for Acetochlor ESA (PDF) Information Sheet: Acetochlor ESA and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 500 | Thyroid (E) | |||
| Subchronic | 500 | Male reproductive system; Thyroid (E) | |||
| Chronic | 300 | Male reproductive system; Thyroid (E) | |||
| Cancer | NA | -- | |||
| 184992-44-4 | Acetochlor OXA (degradate of Acetochlor) Toxicological Summary for Acetochlor OXA (PDF) Information Sheet: Acetochlor OXA and Drinking Water |
HRL18 | Acute | ND | -- |
| Short-term | 100 | Thyroid (E) | |||
| Subchronic | 100* | Thyroid (E) | |||
| Chronic | 90 | Thyroid (E) | |||
| Cancer | NA | -- | |||
| 67-64-1 | Acetone Toxicological Summary for Acetone (HRL 2011) (PDF) |
HRL11*** | Acute | ND | -- |
| Short-term | 9,000 | Kidney system | |||
| Subchronic | 8,000 | Kidney system; Blood system | |||
| Chronic | 4,000 | Kidney system; Blood system | |||
| Cancer | NA | -- | |||
| Acetone Toxicological Summary for Acetone (HBV 2020) (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | 5,000 | Kidney system | |||
| Subchronic | 5,000* | Kidney system | |||
| Chronic | 3,000 | Blood system; Liver system; Kidney system | |||
| Cancer | NA | -- | |||
| 21145-77-7 or 1506-02-1 | 6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN or Tonalide) Toxicological Summary for 6-Acetyl-1,12,4,4,7-hexamethyltetraline (PDF) Information Sheet: AHTN in Drinking Water (PDF) |
HRL13 | Acute | ND | -- |
| Short-term | 100 | Liver system | |||
| Subchronic | 30 | Liver system | |||
| Chronic | 20 | Liver system | |||
| Cancer | NA | -- | |||
| 79-06-1 | Acrylamide Toxicological Summary for Acrylamide (PDF) Information Sheet: Acrylamide in Drinking Water (PDF) |
HRL15 | Acute | ND | -- |
| Short-term | 7 | Developmental; Male reproductive system; Nervous system | |||
| Subchronic | 7* | Developmental; Male reproductive system; Nervous system | |||
| Chronic | 7* | Developmental; Male reproductive system; Nervous system | |||
| Cancer | 0.2 | Cancer | |||
| 15972-60-8 | Alachlor Toxicological Summary for Alachlor (PDF) See also degradates Alachlor ESA Alachlor OXA Information Sheet: Alachlor and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 100 | Developmental; Kidney system | |||
| Subchronic | 60 | Blood system; Liver system; Kidney system | |||
| Chronic | 9 | Blood system; Liver system; Kidney system | |||
| Cancer | NA | -- | |||
| 142363-53-9 | Alachlor ESA Toxicological Summary for Alachlor ESA (PDF) (degradate of Alachlor) |
RAA16 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 100 | Blood system | |||
| Chronic | 50 | Blood system | |||
| Cancer | NA | -- | |||
| 171262-17-2 | Alachlor OXA Toxicological Summary for Alachlor OXA (PDF) (degradate of Alachlor) |
RAA16 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 100 | Blood system | |||
| Chronic | 50 | Blood system | |||
| Cancer | NA | -- | |||
| 116-06-3 | Aldicarb | HRL93 | Chronic | 1 | Nervous system |
| 107-05-1 | Allyl chloride (3 chloropropene) | HRL94 | Chronic | 30 | Nervous system |
| 1066-51-9 | Aminomethylphosphonic acid (AMPA) Toxicological Summary for Aminomethylphosphonic acid (PDF) Information Sheet: AMPA and Drinking Water (PDF) |
HBV22 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 3000 | Liver system; Kidney system | |||
| Chronic | 1000 | Liver system; Kidney system | |||
| Cancer | NA | -- | |||
| 64285-06-9 | Anatoxin-a Toxicological Summary for Anatoxin-a (PDF) Information Sheet: Anatoxin-a in Drinking Water (PDF) |
RAA16 | Acute | ND | -- |
| Short-term | 0.1 | Nervous system | |||
| Subchronic | ND | -- | |||
| Chronic | ND | -- | |||
| Cancer | ND | -- | |||
| 120-12-7 | Anthracene Toxicological Summary for Anthracene (PDF) Information Sheet: Anthracene and Groundwater (PDF) |
HRL93*** | Chronic | 2,000 | None |
| RAA19 | Acute | ND | -- | ||
| Short-term | ND | -- | |||
| Subchronic | 1,000 | NA | |||
| Chronic | 600 | NA | |||
| Cancer | NA | -- | |||
| 7440-36-0 | Antimony | HRL93 | Chronic | 6 | -- |
| 1912-24-9 | Atrazine
See also degradates Deethylatrazine, Deethyldeisopropylatrazine, and Deisopropylatrazine as described in the Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) |
HRLMCL | Chronic | 3 | see USEPA Organic Chemicals table |
| 7440-39-3 | Barium | HRL93 | Chronic | 2,000 | Cardiovascular system |
| 25057-89-0 | Bentazon Toxicological Summary for Bentazon (PDF) Information Sheet: Bentazon in Drinking Water (PDF) |
HRL15 | Acute | 400 | Developmental; Female reproductive system |
| Short-term | 60 | Developmental | |||
| Subchronic | 50 | Blood system | |||
| Chronic | 30 | Thyroid | |||
| Cancer | NA | -- | |||
| 71-43-2 | Benzene Toxicological Summary for Benzene (PDF) |
HRL09 | Acute | 10 | Developmental |
| Short-term | 10 | Blood system; Immune system | |||
| Subchronic | 3 | Blood system; Immune system | |||
| Chronic | 3** | Blood system; Immune system | |||
| Cancer | 2 | Cancer | |||
| 50-32-8 | Benzo[a]pyrene Toxicological Summary for Benzo(a)pyrene (PDF) Information Sheet: Benzo(a)pyrene and Groundwater (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 0.5 | Developmental; Nervous system | |||
| Subchronic | 0.5* | Developmental; Nervous system | |||
| Chronic | 0.5* | Developmental; Nervous system | |||
| Cancer | 0.1 | Cancer | |||
| Go to > top. | |||||
| 65-85-0 | Benzoic acid | HRL93 | Chronic | 30,000 | None |
| 119-61-9 | Benzophenone Toxicological Summary for Benzophenone (PDF) Information Sheet: Benzophenone and Groundwater (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 900 | Developmental | |||
| Subchronic | 100 | Liver System; Kidney System | |||
| Chronic | 100** | Liver System; Kidney System | |||
| Cancer | NA | -- | |||
| 95-14-7 | 1H-Benzotriazole Toxicological Summary for 1H-Benzotriazole (PDF) Information Sheet: 1H-Benzotriazole, Tolyltriazole, 5-Methyl-1H-Benzotriazole and Groundwater (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 20 | Developmental | |||
| Subchronic | 20* | Developmental | |||
| Chronic | 20* | Developmental | |||
| Cancer | NA | -- | |||
| 29385-43-1 | methyl-1H-Benzotriazole (Tolyltriazole) Toxicological Summary for Tolyltriazole and 5-methyl-1H-Benzotriazole (PDF) Information Sheet: 1H-Benzotriazole, Tolyltriazole, 5-Methyl-1H-Benzotriazole and Groundwater (PDF) |
RAA19 | Acute | ND | -- |
| Short-term | 20 | Developmental | |||
| Subchronic | 20* | Developmental | |||
| Chronic | 20* | Developmental | |||
| Cancer | NA | -- | |||
| 136-85-6 | 5-methyl-1H-Benzotriazole Toxicological Summary for Tolyltriazole and 5-methyl-1H-Benzotriazole (PDF) Information Sheet: 1H-Benzotriazole, Tolytriazole, 5-Methyl-1H-Benzotriazole and Groundwater (PDF) |
RAA19 | Acute | ND | -- |
| Short-term | 20 | Developmental | |||
| Subchronic | 20* | Developmental | |||
| Chronic | 20* | Developmental | |||
| Cancer | NA | -- | |||
| 7440-41-7 | Beryllium | HRL93 | Cancer | 0.08 | Cancer |
| 92-52-4 | 1,1'-Biphenyl (Diphenyl) Toxicological Summary for 1,1'-Biphenyl (PDF) |
HRL93 | Chronic | 300 | Kidney system |
| HBV21 | Acute | 400 | Kidney system | ||
| Short-term | 100 | Kidney system | |||
| Subchronic | 100* | Kidney system | |||
| Chronic | 100* | Kidney system | |||
| Cancer | 10 | Cancer | |||
| 111-44-4 | Bis(chloroethyl) ether (BCEE) | HRL93 | Cancer | 0.3 | Cancer |
| 542-88-1 | Bis(chloromethyl) ether (BCME) | HRL93 | Cancer | 0.002 | Cancer |
| 80-05-7 | Bisphenol A (BPA) Toxicological Summary for Bisphenol A (PDF) Information Sheet: Bisphenol A in Drinking Water (PDF) |
HRL15 | Acute | ND | -- |
| Short-term | 100 | Developmental; Female reproductive system (E); Liver system; Male reproductive system (E); Kidney system; Thyroid (E) | |||
| Subchronic | 20 | Liver system; Kidney system | |||
| Chronic | 20** | Liver system; Kidney system | |||
| Cancer | NA | -- | |||
| 7440-42-8 | Boron Toxicological Summary for Boron (PDF) Information Sheet: Boron and Drinking Water (PDF) |
RAA17 | Acute | ND | -- |
| Short-term | 500 | Developmental | |||
| Subchronic | 500 | Developmental | |||
| Chronic | 500 | Developmental | |||
| Cancer | NA | -- | |||
| 75-27-4 | Bromodichloromethane Toxicological Summary for Bromodichloromethane (PDF) Information Sheet: Bromodichloromethane and Groundwater (PDF) |
HRL93 | Cancer | 6 | Cancer |
| HBV20 | Acute | 400 | Female reproductive system (E) | ||
| Short-term | 30 | Immune system; Spleen | |||
| Subchronic | 30* | Immune system; Spleen | |||
| Chronic | 30 | Liver system | |||
| Cancer | 3 | Cancer | |||
| 75-25-2 | Bromoform | HRL93 | Cancer | 40 | Cancer |
| 74-83-9 | Bromomethane (Methyl bromide) | HRL93 | Chronic | 10 | Gastrointestinal system |
| 71-36-3 | n-Butanol | HRL93 | Chronic | 700 | Nervous system |
| 85-68-7 | Butyl benzyl phthalate (BBP) Toxicological Summary for Butyl benzyl phthalate (PDF) Information Sheet: Phthalates and Drinking Water (PDF) |
HRL15 | Acute | 100 | Developmental (E) |
| Short-term | 100 | Developmental (E) | |||
| Subchronic | 100* | Developmental (E) | |||
| Chronic | 100* | Developmental (E) | |||
| Cancer | NA | -- | |||
| 85-70-1 | Butylphthalyl butylglycolate (BPBG) | HRL93 | Chronic | 7,000 | None |
| 7440-43-9 | Cadmium Toxicological Summary for Cadmium (PDF) Information sheet: Cadmium and Drinking Water (PDF) |
HRL15 | Acute | 5 | Developmental |
| Short-term | 1 | Developmental; Nervous system; Kidney system | |||
| Subchronic | 1 | Developmental; Skeletal | |||
| Chronic | 0.5 | Kidney system; Skeletal | |||
| Cancer | NA | -- | |||
| 298-46-4 | Carbamazepine Toxicological Summary for Carbamazepine (PDF) Information Sheet: Carbamazepine in Drinking Water (PDF) |
HRL13 | Acute | 40 | Developmental; Nervous system |
| Short-term | 40 | Developmental; Blood system; Liver system; Immune system; Nervous system; Male reproductive system (E); Female reproductive system (E); Thyroid (E) |
|||
| Subchronic | 40* | Developmental; Blood system; Liver system; Immune system; Nervous system; Male reproductive system (E); Female reproductive system (E);Thyroid (E) | |||
| Chronic | 40* | Developmental; Blood system; Liver system; Immune system; Nervous system; Male reproductive system (E); Female reproductive system (E); Thyroid (E) | |||
| Cancer | NA | -- | |||
| 75-15-0 | Carbon disulfide | HRL93 | Chronic | 700 | Developmental |
| 56-23-5 | Carbon tetrachloride Toxicological Summary for Carbon tetrachloride (PDF) |
HRL13 | Acute | 100 | Developmental; Liver system |
| Short-term | 3 | Liver system | |||
| Subchronic | 3* | Liver system | |||
| Chronic | 3* | Liver system | |||
| Cancer | 1 | Cancer | |||
| 133-90-4 | Chloramben | HRL94 | Chronic | 100 | Liver system |
| 108-90-7 | Chlorobenzene | HRL93 | Chronic | 100 | Liver system |
| 75-00-3 | Chloroethane Toxicological Summary for Chloroethane (PDF) |
RAA16 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | ND | -- | |||
| Chronic | ND | -- | |||
| Cancer | NA | -- | |||
| 67-66-3 | Chloroform Toxicological Summary for Chloroform (PDF) Information Sheet: Chloroform and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 20 | Developmental; Liver system; Immune system | |||
| Subchronic | 20* | Developmental; Liver system; Immune system | |||
| Chronic | 20* | Developmental; Liver system; Immune system | |||
| Cancer | NA | -- | |||
| 95-57-8 | 2-Chlorophenol | HRL93 | Chronic | 30 | Developmental |
| 1897-45-6 | Chlorothalonil | HRL94 | Cancer | 30 | Cancer |
| 2921-88-2 | Chlorpyrifos Toxicological Summary for Chlorpyrifos (PDF) Information Sheet: Chlorpyrifos and Drinking Water (PDF) |
HBV13 | Acute | 2 | Nervous system |
| Short-term | 0.6 | Nervous system | |||
| Subchronic | 0.6* | Nervous system | |||
| Chronic | 0.6* | Nervous system | |||
| Cancer | NA | -- | |||
| 5598-15-2 | Chlorpyrifos Oxon (degradate of Chlorpyrifos) Toxicological Summary for Chlorpyrifos Oxon (PDF) Information Sheet: Chlorpyrifos and Drinking Water (PDF) |
RAA13 | Acute | 0.9 | Nervous system |
| Short-term | 0.4 | Nervous system | |||
| Subchronic | 0.4* | Nervous system | |||
| Chronic | 0.4* | Nervous system | |||
| Cancer | NA | -- | |||
| 16065-83-1 | Chromium III | HRL94 | Chronic | 20,000 | None |
| 18540-29-9 | Chromium VI | HRL93 | Chronic | 100 | None |
| 210880-92-5; 205510-53-8 | Clothianidin Toxicological Summary for Clothianidin (PDF) Information Sheet: Clothianidin and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 200 | Developmental | |||
| Subchronic | 200* | Developmental | |||
| Chronic | 200* | Developmental | |||
| Cancer | NA | -- | |||
| 98-82-8 | Cumene (Isopropyl benzene) | HRL93 | Chronic | 300 | None |
| 21725-46-2 | Cyanazine Toxicological Summary for Cyanazine (PDF) See also degradates Cyanazine acid, Cyanazine amide, Deethylcyanazine, Deethylcyanazine acid, Deethylcyanazine amide, Deethyldeisopropylatrazine, and Deisopropylatrazine as described in the Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF). |
HRL18 | Acute | 3 | Developmental; Female reproductive system |
| Short-term | 3 | Developmental; Female reproductive system | |||
| Subchronic | 3 | Developmental; Female reproductive system; Liver system; Kidney system | |||
| Chronic | 1 | None | |||
| Cancer | NA | -- | |||
| 36576-43-9; 36576-42-8 |
Cyanazine acid (CAC) and Cyanazine amide (CAM) (degradates of Cyanazine) Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) |
RAA20 | Acute | 3 | Developmental; Female reproductive system |
| Short-term | 3 | Developmental; Female reproductive system | |||
| Subchronic | 3 | Developmental; Female reproductive system; Liver system; Kidney system | |||
| Chronic | 1 | None | |||
| Cancer | NA | -- | |||
| 57-12-5 | Cyanide, free | HRL93 | Chronic | 100 | Nervous system; Thyroid (E) |
| Go to > top. | |||||
| 6190-65-4 | Deethylatrazine (DEA) (degradate of Atrazine) Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) |
RAA20 | Chronic | 3 | None |
| 21725-40-6; 36749-35-6; 36556-77-1 |
Deethylcyanazine (DEC), Deethylcyanazine acid (DCAC), and Deethylcyanazine amide (DCAM) (degradates of Cyanazine) Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) |
RAA20 | Acute | 3 | Developmental; Female reproductive system |
| Short-term | 3 | Developmental; Female reproductive system | |||
| Subchronic | 3 | Developmental; Female reproductive system; Liver system; Kidney system | |||
| Chronic | 1 | None | |||
| Cancer | NA | -- | |||
| 3397-62-4; 1007-28-9 |
Deethyldeisopropylatrazine (DACT, DEDI, DDA) and Deisopropylatrazine (DIA) (degradates of Atrazine and Cyanazine) Toxicological Summary for Cyanazine and Atrazine Chlorinated Degradates (PDF) |
RAA20 | Use Cyanazine HRL values if Cyanazine, CAC, CAM, DEC, DCAC or DCAM are present. Use Atrazine HRL value if Cyanazine, CAC, CAM, DEC, DCAC or DCAM are not present. | ||
| 93413-62-8; 386750-22-7; 300827-87-6; 93414-04-1 | Desvenlafaxine Toxicological Summary for Desvenlafaxine (PDF) Information Sheet: Venlafaxine and Desvenlafaxine and Drinking Water (PDF) |
HBV15 | Acute | ND | -- |
| Short-term | 20 | Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E) | |||
| Subchronic | 20* | Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E) | |||
| Chronic | 20* | Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E) | |||
| Cancer | NA | -- | |||
| 124-48-1 | Dibromochloromethane | HRL93 | Chronic | 10 | Liver system |
| 106-93-4 | 1,2-Dibromoethane (ethylene dibromide, EDB) | HRL93 | Cancer | 0.004 | Cancer |
| 84-74-2 | Dibutyl phthalate (DBP) Toxicological Summary for Dibutyl phthalate (PDF) Information Sheet: Phthalates and Drinking Water (PDF) |
HRL15 | Acute | 20 | Developmental (E) |
| Short-term | 20 | Developmental (E) | |||
| Subchronic | 20* | Developmental (E) | |||
| Chronic | 20* | Developmental (E) | |||
| Cancer | NA | -- | |||
| 1918-00-9 | Dicamba | HRL93*** | Chronic | 200 | Developmental |
| 95-50-1 | 1,2-Dichlorobenzene | HRL93 | Chronic | 600 | Liver system |
| 106-46-7 | 1,4-Dichlorobenzene (para) | HRL94*** | Cancer | 10 | Cancer |
| 1,4-Dichlorobenzene Toxicological Summary for 1,4-Dichlorobenzene (PDF) Information Sheet: 1,4-Dichlorobenzene and Groundwater (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | 50 | Developmental; Liver system; Nervous system | |||
| Subchronic | 50* | Developmental; Liver system; Nervous system | |||
| Chronic | 50* | Developmental; Liver system; Nervous system | |||
| Cancer | NA | -- | |||
| 91-94-1 | 3,3'-Dichlorobenzidine | HRL93 | Cancer | 0.8 | Cancer |
| 75-71-8 | Dichlorodifluoromethane Toxicological Summary for Dichlorodifluoromethane (PDFs) |
HRL11*** | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | ND | -- | |||
| Chronic | 700 | None | |||
| Cancer | NA | -- | |||
| Dichlorodifluoromethane Toxicological Summary for Dichlorodifluoromethane (PDF) Information Sheet: Dichlorodifluoromethane and Drinking Water (PDF) |
RAA17 | Acute | ND | -- | |
| Short-term | ND | -- | |||
| Subchronic | ND | -- | |||
| Chronic | 500 | None | |||
| Cancer | NA | -- | |||
| 72-54-8 | p,p'-Dichlorodiphenyldichloroethane (DDD) | HRL93 | Cancer | 1 | Cancer |
| 72-55-9 | p,p'-Dichlorodiphenyldichloroethylene (DDE) | HRL93 | Cancer | 1 | Cancer |
| 50-29-3 | p,p'-Dichlorodiphenyltrichloroethane (DDT) | HRL93 | Cancer | 1 | Cancer |
| 75-34-3 | 1,1-Dichloroethane Toxicological Summary for 1,1-Dichloroethane (PDF) |
RAA16 | Acute | ND | -- |
| Short-term | 400 | Nervous system | |||
| Subchronic | 400* | Nervous system | |||
| Chronic | 80 | Nervous system | |||
| Cancer | NA | -- | |||
| 107-06-2 | 1,2-Dichloroethane Toxicological Summary for 1,2-Dichloroethane (PDF) |
HRL13 | Acute | ND | -- |
| Short-term | 200 | Liver system | |||
| Subchronic | 200* | Liver system | |||
| Chronic | 60 | Kidney system; Liver system | |||
| Cancer | 1 | Cancer | |||
| 156-59-2 | cis-1,2-Dichloroethene Toxicological Summary for cis-1,2-Dichloroethene (PDF) Information sheet: cis-1,2-Dichloroethene and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 20 | Liver system | |||
| Subchronic | 10 | Kidney system | |||
| Chronic | 6 | Kidney system | |||
| Cancer | NA | -- | |||
| 156-60-5 | trans-1,2-Dichloroethene Toxicological Summary for trans-1,2-Dichloroethene (PDF) |
HRL13 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 200 | Immune system | |||
| Chronic | 40 | Immune system | |||
| Cancer | NA | -- | |||
| trans-1,2-Dichloroethene Toxicological Summary for trans-1,2-Dichloroethene (HBV 2020) (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | ND | -- | |||
| Subchronic | 50 | Immune system | |||
| Chronic | 9 | Immune system | |||
| Cancer | NA | -- | |||
| 75-35-4 | 1,1-Dichloroethylene (Vinylidene chloride) Toxicological Summary for 1,1-Dichloroethylene (Vinylidene chloride) (PDF) |
HRL11*** | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 200 | Liver system | |||
| Chronic | 200 | Liver system | |||
| Cancer | NA | -- | |||
| 1,1-Dichloroethylene (Vinylidene chloride) Toxicological Summary for 1,1-Dichloroethylene (Vinylidene chloride) (2020) (PDF) Information Sheet: 1,1-Dichloroethylene and Groundwater (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | ND | -- | |||
| Subchronic | 200 | Liver system | |||
| Chronic | 200 | Liver system | |||
| Cancer | NA | -- | |||
| 75-43-4 | Dichlorofluoromethane (DCFM) Toxicological Summary for Dichlorofluoromethane (PDF) Information sheet: Dichlorofluoromethane and Drinking Water (PDF) |
RAA17 | Acute | ND | -- |
| Short-term | 20 | Developmental; Liver system; Immune system | |||
| Subchronic | 20* | Developmental; Liver system; Immune system; | |||
| Chronic | 20* | Developmental; Liver system; Immune system; | |||
| Cancer | NA | -- | |||
| 75-09-2 | Dichloromethane (Methylene chloride) | HRLMCL | Chronic | 5 | see USEPA Organic Chemicals table |
| 120-83-2 | 2,4-Dichlorophenol | HRL93 | Chronic | 20 | Immune system |
| 94-75-7 | 2,4-Dichlorophenoxyacetic acid (2,4-D) Toxicological Summary for 2,4-Dichlorophenoxyacetic acid (PDF) Information Sheet: 2.4-D and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 30 | Adrenal; Developmental; Thyroid (E) | |||
| Subchronic | 30* | Adrenal; Developmental; Thyroid (E) | |||
| Chronic | 30* | Adrenal; Developmental; Thyroid (E) | |||
| Cancer | ND | -- | |||
| 78-87-5 | 1,2-Dichloropropane Toxiocological Summary for 1,2-Dichloropropane (HBV 2021) (PDF) |
HRL94 | Cancer | 5 | Cancer |
| HBV21 | Acute | ND | -- | ||
| Short-term | 20 | Developmental | |||
| Subchronic | 20* | Developmental | |||
| Chronic | 20* | Developmental | |||
| Cancer | 3 | Cancer | |||
| 542-75-6 | 1,3-Dichloropropene | HRL94 | Cancer | 2 | Cancer |
| 60-57-1 | Dieldrin Toxicological Summary for Dieldrin (PDF) Information Sheet: Dieldrin and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 0.2 | Developmental; Immune system; Nervous system | |||
| Subchronic | 0.2* | Developmental; Immune system; Nervous system | |||
| Chronic | 0.2 | Developmental; Liver system; Immune system; Nervous system | |||
| Cancer | 0.006 | Cancer | |||
| 134-62-3 | N,N-Diethyl-meta-toluamide (DEET) Toxicological Summary for N,N-Diethyl-meta-toluamide (DEET) (PDF) Information Sheet: DEET in Drinking Water (PDF) |
HRL13 | Acute | ND | -- |
| Short-term | 200 | Developmental; Nervous system | |||
| Subchronic | 200* | Developmental; Nervous system | |||
| Chronic | 200* | Developmental; Nervous system | |||
| Cancer | NA | -- | |||
| Go to > top. | |||||
| 117-81-7 | Di(2-ethylhexyl)phthalate (DEHP) Toxicological Summary for Di(2-ethylhexyl) phthalate (PDF) Information Sheet: Phthalates and Drinking Water (PDF) |
HRL15 | Acute | 20 | Developmental (E); Male reproductive system (E) |
| Short-term | 20 | Developmental (E); Male reproductive system (E) | |||
| Subchronic | 20* | Developmental (E); Male reproductive system (E) | |||
| Chronic | 20* | Developmental (E); Male reproductive system (E) | |||
| Cancer | 7 | Cancer | |||
| 84-66-2 | Diethyl phthalate | HRL93 | Chronic | 6,000 | None |
| 87674-68-8 163515-14-8 |
Dimethenamid & Dimethenamid-P Toxicological Summary for Dimethenamid & Dimethenamid-P (PDF) Information Sheet: Dimethenamid and Drinking Water (PDF) See also degradates: Dimethenamid ESA & Dimethenamid OXA (PDF) |
HRL15 |
Acute | ND | -- |
| Short-term | 600 | Developmental; Liver system; Nervous system; Female reproductive system | |||
| Subchronic | 600* | Developmental; Liver system; Nervous system; Female reproductive system | |||
| Chronic | 300 | Liver system | |||
| Cancer | NA | -- | |||
| 205939-58-8, 380412-59-9 | Dimethenamid ESA Dimethenamid OXA Toxicological Summary for Dimethenamid Degradates: ESA and OXA (PDF) Information Sheet: Dimethenamid and Drinking Water (PDF) |
RAA13 |
Acute | ND | -- |
| Short-term | 600 | Developmental; Liver system; Nervous system; Female reproductive system | |||
| Subchronic | 600 | Developmental; Liver system; Nervous system; Female reproductive system | |||
| Chronic | 300 | Liver system | |||
| Cancer | NA | -- | |||
| 105-67-9 | 2,4-Dimethylphenol | HRL93 | Chronic | 100 | Blood system; Nervous system |
| 131-11-3 | Dimethylphthalate | HRL94 | Chronic | 70,000 | Kidney system |
| 51-28-5 | 2,4-Dinitrophenol | HRL94 | Chronic | 10 | Eyes |
| 88-85-7 | Dinoseb Toxicological Summary for Dinoseb (PDF) Information Sheet: Dinoseb and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 8 | Developmental | |||
| Subchronic | 8* | Developmental | |||
| Chronic | 8* | Developmental | |||
| Cancer | NA | -- | |||
| 123-91-1 | 1,4-Dioxane Toxicological Summary for 1,4-Dioxane (PDF) Information Sheet: 1,4-Dioxane in Drinking Water (PDF) |
HRL13 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 300 | Liver system; Kidney system; Respiratory system | |||
| Chronic | 100 | Liver system; Kidney system; Respiratory system | |||
| Cancer | 1 | Cancer | |||
| 298-04-4 | Disulfoton | HRL94 | Chronic | 0.3 | Nervous system |
| 57-63-6 | 17α-Ethinylestradiol Toxicological Summary for 17α-Ethinylestradiol (PDF) Information Sheet: 17α-Ethinylestradiol and Mestranol and Drinking Water (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 0.0005 | Developmental (E); Female Reproductive system (E); Male Reproductive system (E) | |||
| Subchronic | 0.0002 | Developmental | |||
| Chronic | 0.0002 | Developmental | |||
| Cancer | ND | -- | |||
| 100-41-4 | Ethylbenzene Toxicological Summary for Ethylbenzene (2011) (PDF) |
HRL11*** | Acute | ND | -- |
| Short-term | 50 | Liver system; Kidney system | |||
| Subchronic | 50* | Liver system; Kidney system | |||
| Chronic | 50* | Liver system; Kidney system | |||
| Cancer | NA | -- | |||
| Ethylbenzene Toxicological Summary for Ethylbenzene (2020) (PDF) Information Sheet: Ethylbenzene and Groundwater (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | 40 | Liver system; Kidney system | |||
| Subchronic | 40* | Liver system; Kidney system | |||
| Chronic | 40* | Liver system; Kidney system | |||
| Cancer | NA | -- | |||
| 759-94-4 | S-Ethyl-N,N-dipropylthiocarbamate (EPTC) Toxicological Summary for S-Ethyl-N,N-dipropylthiocarbamate (PDF) Information Sheet: S-Ethyl-N,N-dipropylthiocarbamate (EPTC) and Drinking Water (PDF) |
HRL18 | Acute | 300 | Nervous system |
| Short-term | 300 | Developmental; Female reproductive system; Nervous system | |||
| Subchronic | 90 | Cardiovascular system | |||
| Chronic | 40 | Cardiovascular system | |||
| Cancer | NA | -- | |||
| 60-29-7 | Ethyl ether Toxicological Summary for Ethyl ether (PDF) |
RAA16 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 1000 | Liver system; Kidney system | |||
| Chronic | 200 | Liver system; Kidney system | |||
| Cancer | NA | -- | |||
| 107-21-1 | Ethylene glycol Toxicological Summary for Ethylene glycol (HRL 2011) (PDF) |
HRL11*** | Acute | 4,000 | Developmental |
| Short-term | 4,000 | Developmental | |||
| Subchronic | 2,000 | Developmental; Kidney system | |||
| Chronic | 2,000 | Developmental; Kidney system | |||
| Cancer | NA | -- | |||
| Ethylene glycol Toxicological Summary for Ethylene glycol (HBV 2020) (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | 2,000 | Developmental | |||
| Subchronic | 2,000 | Developmental; Kidney system | |||
| Chronic | 2,000 | Developmental; Male reproductive system; Kidney system | |||
| Cancer | NA | -- | |||
| 206-44-0 | Fluoranthene
Toxicological Summary for Fluoranthene (PDF) Information Sheet: Fluoranthene in Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 200 | Liver system; Kidney system | |||
| Chronic | 70 | Liver system; Kidney system | |||
| Cancer | NA | see Guidance for Evaluating the Cancer Potency of PAH Mixtures (PDF) | |||
| 86-73-7 | Fluorene (9H-Fluorene) Toxicological Summary for Fluorene (PDF) Information Sheet: Fluorene and Groundwater (PDF) |
HRL93*** | Chronic | 300 | Blood system |
| HBV20 | Acute | ND | -- | ||
| Short-term | ND | -- | |||
| Subchronic | 200 | Blood system; Spleen | |||
| Chronic | 80 | Blood system; Spleen | |||
| Cancer | NA | -- | |||
| 72178-02-0 | Fomesafen Toxicological Summary for Fomesafen (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 200 | Developmental; Liver system; Immune system | |||
| Subchronic | 200* | Developmental; Liver system; Immune system | |||
| Chronic | 20 | Liver system | |||
| Cancer | NA | -- | |||
| 50-00-0 | Formaldehyde | HRL94 | Chronic | 1,000 | Gastrointestinal system |
| 1071-83-6; 38641-94-0; 40465-76-7; 34494-04-7; 114370-14-8; 39600-42-5 | Glyphosate Toxicological Summary for Glyphosate (PDF) Information Sheet: Glyphosate and Drinking Water (PDF) |
HBV17 | Acute | ND | -- |
| Short-term | 1,000 | Developmental | |||
| Subchronic | 1,000 | Gastrointestinal system | |||
| Chronic | 500 | Gastrointestinal system | |||
| Cancer | NA | -- | |||
| 76-44-8 | Heptachlor | HRL93 | Cancer | 0.08 | Cancer |
| 1024-57-3 | Heptachlor epoxide | HRL93 | Cancer | 0.04 | Cancer |
| 118-74-1 | Hexachlorobenzene | HRL93 | Cancer | 0.2 | Cancer |
| 87-68-3 | Hexachlorobutadiene | HRL93 | Chronic | 1 | Kidney system |
| 110-54-3 | Hexane (n-hexane) | HRL94 | Chronic | 400 | Nervous system |
| Hexane (n-hexane) Toxicological Summary for n-Hexane (2022) (PDF) |
RAA22 | Acute | ND | -- | |
| Short-term | 100 | Nervous system | |||
| Subchronic | 100* | Nervous system | |||
| Chronic | 80 | Nervous system | |||
| Cancer | NA | -- | |||
| 138261-41-3 | Imidacloprid Toxicological Summary for Imidacloprid (PDF) Information Sheet: Imidacloprid and Groundwater (PDF) |
HBV20 | Acute | 100 | Nervous system |
| Short-term | 2 | Immune system | |||
| Subchronic | 2* | Immune system | |||
| Chronic | 2* | Immune system | |||
| Cancer | NA | -- | |||
| 78-83-1 | Isobutanol Toxicological Summary for Isobutanol (PDF) Information Sheet: Isobutanol and Drinking Water (PDF) |
HBV16 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 700 | Male reproductive system | |||
| Chronic | 300 | Male reproductive system | |||
| Cancer | NA | -- | |||
| 78-59-1 | Isophorone | HRL93 | Chronic | 100 | Kidney system |
| 330-55-2 | Linuron | HRL93 | Chronic | 1 | Blood system |
| 7439-96-5 | Manganese Toxicological Summary for Manganese (PDF) Manganese in Drinking Water |
HRL93*** | Chronic | 100 | Nervous system |
| HBV20 | Acute | ND | -- | ||
| Short-term | 100 | Developmental; Nervous system | |||
| Subchronic | ND | -- | |||
| Chronic | ND | -- | |||
| Cancer | NA | -- | |||
| 72-33-3 | Mestranol Toxicological Summary for Mestranol (PDF) Information Sheet: 17α-Ethinylestradiol and Mestranol and Drinking Water (PDF) |
RAA16 | Acute | ND | -- |
| Short-term | 0.0007 | Developmental (E); Female Reproductive system (E); Male Reproductive system (E) | |||
| Subchronic | 0.0002 | Developmental | |||
| Chronic | 0.0002** | Developmental | |||
| Cancer | ND | -- | |||
| 67-56-1 | Methanol | HRL94 | Chronic | 3,000 | Liver system; Nervous system |
| 94-74-6 | 2-Methyl-4-chlorophenoxyacetic acid (MCPA) | HRL93 | Chronic | 3 | Liver system; Kidney system |
| 78-93-3 | Methyl ethyl ketone (MEK, 2-butanone) | HRL94 | Chronic | 4,000 | Developmental |
| 108-10-1 | Methyl isobutyl ketone (MIBK) | HRL94 | Chronic | 300 | Liver system; Kidney system |
| 1634-04-4 | Methyl tert-butyl ether (MTBE) Toxicological Summary for Methyl tert-butyl ether (MTBE) (PDF) Information Sheet for Methyl tert-butyl ether (MTBE) and Drinking Water (PDF) |
RAA13 | Acute | ND | -- |
| Short-term | 700 | Liver system; Nervous system; Kidney system | |||
| Subchronic | 700* | Liver system; Nervous system; Kidney system | |||
| Chronic | 700* | Liver system; Nervous system; Kidney system | |||
| Cancer | 60 | Cancer | |||
| 91-57-6 | 2-Methylnaphthalene Toxicological Summary for 2-Methylnaphthalene (PDF) Information Sheet: 2-Methylnaphthalene and Drinking Water (PDF) |
RAA13 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | ND | -- | |||
| Chronic | 8 | Respiratory system | |||
| Cancer | ND | -- | |||
| 95-48-7 | 2-Methylphenol (o-cresol) | HRL93 | Chronic | 30 | Nervous system |
| 108-39-4 | 3-Methylphenol (m-cresol) | HRL93 | Chronic | 30 | Nervous system |
| 106-44-5 | 4-Methylphenol (p-cresol) | HRL94 | Chronic | 3 | None |
| 51218-45-2; 87392-12-9 |
Metolachlor and s-Metolachlor Toxicological Summary for Metolachlor and s-Metolachlor (HRL 2011) (PDF) See also degradates Metolachlor ESA Metolachlor OXA |
HRL11*** | Acute | 400 | Developmental |
| Short-term | 400 | Developmental | |||
| Subchronic | 300 | None | |||
| Chronic | 300** | None | |||
| Cancer | NA | -- | |||
| Metolachlor and s-Metolachlor Toxicological Summary for Metolachlor and s-Metolachlor (HBV 2020) (PDF) Information Sheet: Metolachlor and Drinking Water (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | 300 | Developmental | |||
| Subchronic | 300* | Developmental | |||
| Chronic | 300* | Developmental | |||
| Cancer | NA | -- | |||
| 171118-09-5 | Metolachlor ESA Toxicological Summary for Metolachlor ESA (HRL 2011) (PDF) (degradate of Metolachlor) |
HRL11*** | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 4,000 | Liver system | |||
| Chronic | 800 | Liver system | |||
| Cancer | NA | -- | |||
| Metolachlor ESA (degradate of Metolachlor) Toxicological Summary for Metolachlor ESA (HBV 2020) (PDF) Information Sheet: Metolachlor ESA/OXA and Drinking Water (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | ND | -- | |||
| Subchronic | 7,000 | Liver system | |||
| Chronic | 1,000 | Liver system | |||
| Cancer | NA | -- | |||
| 152019-73-3 | Metolachlor OXA Toxicological Summary for Metolachlor OXA (HRL 2011) (PDF) (degradate of Metolachlor) |
HRL11*** | Acute | ND | -- |
| Short-term | 3,000 | None | |||
| Subchronic | 3,000* | None | |||
| Chronic | 800 | None | |||
| Cancer | NA | -- | |||
| Metolachlor OXA (degradate of Metolachlor) Toxicological Summary for Metolachlor OXA (HBV 2020) (PDF) Information Sheet: Metolachlor ESA/OXA and Drinking Water (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | 5,000 | None | |||
| Subchronic | 5,000* | None | |||
| Chronic | 1,000 | None | |||
| Cancer | NA | -- | |||
| 21087-64-9 | Metribuzin Toxicological Summary for Metribuzin (PDF) See also degradates: Metribuzin DA, DK, and DADK (PDF) |
HRL13 | Acute | 30 | Developmental; Nervous system |
| Short-term | 10 | Thyroid (E) | |||
| Subchronic | 10* | Thyroid (E) | |||
| Chronic | 10* | Thyroid (E) | |||
| Cancer | NA | -- | |||
| 35045-02-4; 56507-37-0; 52236-30-3 |
Metribuzin DA, DK, and DADK Toxicological Summary for Metribuzin Degradates DA, DK, and DADK (PDF) Information Sheet: Metribuzin Degradates in Drinking Water (PDF) |
RAA12 | Acute | 30 | Developmental; Nervous system |
| Short-term | 10 | Thyroid (E) | |||
| Subchronic | 10* | Thyroid (E) | |||
| Chronic | 10* | Thyroid (E) | |||
| Cancer | NA | -- | |||
| 101043-37-2 |
Microcystin-LR Toxicological Summary for Microcystin-LR (PDF) Information Sheet: Microcystin-LR in Drinking Water (PDF) |
HBV15 | Acute | NA | -- |
| Short-term | 0.1 | Liver System | |||
| Subchronic | 0.1* | Liver System | |||
| Chronic | 0.1 | Liver System | |||
| Cancer | NA | -- | |||
| Go to > top. | |||||
| 91-20-3 | Naphthalene Toxicological Summary for Naphthalene (PDF) |
HRL13 | Acute | 70 | Nervous system |
| Short-term | 70 | Nervous system | |||
| Subchronic | 70* | Nervous system | |||
| Chronic | 70 | Nervous system; Spleen | |||
| Cancer | NA | -- | |||
| 7440-02-0 | Nickel, soluble salts | HRL93 | Chronic | 100 | None |
| 14797-55-8 | Nitrate (as nitrogen) | HRLMCL | Acute | 10,000 | see USEPA Inorganic Chemicals table |
| 62-75-9 | N-Nitrosodimethylamine (NDMA) Toxicological Summary for N-Nitrosodimethylamine (NDMA) (PDF) Information Sheet: N- Nitrosodimethylamine and Water (PDF) |
HBV17 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | ND | -- | |||
| Chronic | ND | -- | |||
| Cancer | 0.005 | Cancer | |||
| 86-30-6 | N-Nitrosodiphenylamine | HRL93 | Cancer | 70 | Cancer |
| 84852-15-3 | Nonylphenol Toxicological Summary for p-Nonylphenol, branched isomers (PDF) Information Sheet: Nonylphenols and Drinking Water (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 100 | Developmental; Female reproductive system | |||
| Subchronic | 40 | Kidney system | |||
| Chronic | 20 | Kidney system | |||
| Cancer | NA | -- | |||
| 140-66-9 | 4-tert-Octylphenol Toxicological Summary for 4-tert-Octylphenol (PDF) Information Sheet: Octylphenol and Drinking Water (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 100 | Developmental | |||
| Subchronic | 100* | Developmental | |||
| Chronic | 100* | Developmental | |||
| Cancer | NA | -- | |||
| 87-86-5 | Pentachlorophenol (PCP) Toxicological Summary for Pentachlorophenol (PCP) (PDF) Information Sheet: Pentachlorophenol and Drinking Water (PDF) |
HRL15 | Acute | 7 | Developmental; Thyroid (E) |
| Short-term | 7 | Developmental (E); Thyroid (E) | |||
| Subchronic | 7* | Developmental (E); Liver system; Immune system; Male Reproductive system; Thyroid (E) | |||
| Chronic | 7* | Developmental (E); Liver system; Immune system; Male Reproductive system; Thyroid (E) | |||
| Cancer | 0.3 | Cancer | |||
| 45187-15-3; 375-73-5; 29420-49-3 68259-10-9 60453-92-1 |
Perfluorobutane sulfonate (PFBS) Toxicological Summary for Perfluorobutane sulfonate (PFBS) (HRL 2011) (PDF) |
HRL11*** | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 9 | Blood system; Liver system; Kidney system | |||
| Chronic | 7 | Blood system; Liver system; Kidney system | |||
| Cancer | NA | -- | |||
| Perfluorobutane sulfonate (PFBS) Toxicological Summary for Perfluorobutane sulfonate (PFBS) (HBV 2022) (PDF) Information Sheet: PFBS and Drinking Water (PDF) |
HBV22 | Acute | ND | -- | |
| Short-term | 0.1 | Thyroid (E) | |||
| Subchronic | 0.1* | Thyroid (E) | |||
| Chronic | 0.1* | Thyroid (E) | |||
| Cancer | NA | -- | |||
| 45048-62-2; 375-22-4 |
Perfluorobutanoate (PFBA) Toxicological Summary for Perfluorobutanoate (PFBA) (PDF) Information Sheet: PFBA and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 7 | Liver system; Thyroid (E) | |||
| Subchronic | 7* | Liver system; Thyroid (E) | |||
| Chronic | 7* | Liver system; Thyroid (E) | |||
| Cancer | NA | -- | |||
| 108427-53-8; 355-46-4; 3871-99-6 |
Perfluorohexane sulfonate (PFHxS) Toxicological Summary for Perfluorohexane sulfonate (PFHxS) (PDF) Information Sheet: PFHxS and Groundwater (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 0.047 | Liver system; Thyroid (E) | |||
| Subchronic | 0.047 | Liver system; Thyroid (E) | |||
| Chronic | 0.047 | Liver system; Thyroid (E) | |||
| Cancer | NA | -- | |||
| 92612-52-7; 307-24-4; 21615-47-4; 2923-26-4 | Perfluorohexanoate (PFHxA) Toxicological Summary for Perfluorohexanoate (PFHxA) (PDF) |
HBV21 | Acute | ND | -- |
| Short-term | 0.2 | Developmental; Thyroid (E) | |||
| Subchronic | 0.2* | Developmental; Thyroid (E) | |||
| Chronic | 0.2* | Developmental; Thyroid (E) | |||
| Cancer | NA | -- | |||
| 45285-51-6; 335-67-1; 335-66-0; 3825-26-1; 2395-00-8; 335-93-3; 335-95-5 |
Perfluorooctanoate (PFOA) Toxicological Summary for Perfluorooctanoate (PFOA) (PDF) Information Sheet: PFOA and Drinking Water (PDF) Toxicokinetic Model Description |
HRL18 | Acute | NA | -- |
| Short-term | 0.035 | Developmental; Liver system; Immune system; Kidney system | |||
| Subchronic | 0.035 | Developmental; Liver system; Immune system; Kidney system | |||
| Chronic | 0.035 | Developmental; Liver system; Immune system; Kidney system | |||
| Cancer | NA | -- | |||
| Perfluorooctanoate (PFOA) Toxicological Summary for Perfluorooctanoate (PFOA) (PDF) Information Sheet: PFOA and Water (PDF) Toxicokinetic Model Description |
HBV22 | Acute | NA | -- | |
| Short-term | 0.035 | Developmental; Liver system; Immune system; Pancreas; Kidney system; Thyroid (E) |
|||
| Subchronic | 0.035 | Developmental; Liver system; Immune system; Pancreas; Kidney system; Thyroid (E) |
|||
| Chronic | 0.035 | Developmental; Liver system; Immune system; Pancreas; Kidney system; Thyroid (E) |
|||
| Cancer | NA | -- | |||
| 45298-90-6; 1763-23-1; 29081-56-9; 70225-14-8; 2795-39-3; 29457-72-5 |
Perfluorooctane Sulfonate (PFOS) and Salts Toxicological Summary for Perfluorooctane Sulfonate (PFOS) and Salts (PDF) |
HRL09*** | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | ND | -- | |||
| Chronic | 0.3 | Developmental; Liver system; Thyroid (E) | |||
| Cancer | NA | -- | |||
| Perfluorooctane Sulfonate (PFOS) Toxicological Summary for Perfluorooctane Sulfonate (PFOS) (2020) (PDF) Information Sheet: PFOS and Drinking Water (PDF) |
HBV20 | Acute | NA | -- | |
| Short-term | 0.015 | Adrenal (E); Developmental; Liver system; Immune system; Thyroid (E) | |||
| Subchronic | 0.015 | Adrenal (E); Developmental; Liver system; Immune system; Thyroid (E) | |||
| Chronic | 0.015 | Adrenal (E); Developmental; Liver system; Immune system; Thyroid (E) | |||
| Cancer | NA | -- | |||
| 108-95-2 | Phenol | HRL93 | Chronic | 4,000 | Developmental |
| 1918-02-1 | Picloram | HRL93 | Chronic | 500 | Liver system |
| 1336-36-3 | Polychlorinated biphenyls (PCBs) | HRL94 | Cancer | 0.04 | Cancer |
| 1610-18-0 | Prometon | HRL93 | Chronic | 100 | None |
| 1918-16-7 | Propachlor | HRL93 | Chronic | 90 | None |
| 175013-18-0 | Pyraclostrobin Toxicological Summary for Pyraclostrobin (PDF) Information Sheet: Pyraclostrobin in Drinking Water (PDF) |
HBV16 | Acute | 300 | Developmental; Female Reproductive system |
| Short-term | 100 | Developmental; Female Reproductive system; Gastrointestinal system; Spleen | |||
| Subchronic | 100 | Developmental; Female Reproductive system; Gastrointestinal system; Blood system; Liver system; Immune system; Spleen | |||
| Chronic | 100** | Developmental; Female Reproductive system; Gastrointestinal system; Blood system; Liver system; Immune system; Spleen | |||
| Cancer | NA | -- | |||
| 129-00-0 | Pyrene Toxicological Summary for Pyrene (PDF) Information Sheet: Pyrene in Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 90 | Kidney system | |||
| Chronic | 50 | Kidney system | |||
| Cancer | NA | -- | |||
| 91-22-5 | Quinoline Toxicological Summary for Quinoline (PDF) Information Sheet: Quinoline and Groundwater (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | ND | -- | |||
| Chronic | 4 | Blood system; Liver system; Kidney system; Respiratory system; Spleen | |||
| Cancer | 0.03 | Cancer | |||
| 7782-49-2 | Selenium | HRL93 | Chronic | 30 | None |
| 7440-22-4 | Silver | HRL93 | Chronic | 30 | None |
| 122-34-9 | Simazine | HRLMCL | Chronic | 4 | see USEPA Organic Chemicals table |
| 7440-24-6 | Strontium Toxicological Summary for Strontium (PDF) Information Sheet: Strontium and Groundwater (PDF) |
RAA19 | Acute | ND | -- |
| Short-term | 3000 | Developmental; Skeletal | |||
| Subchronic | 3000* | Developmental; Skeletal | |||
| Chronic | 3000* | Developmental; Skeletal | |||
| Cancer | NA | -- | |||
| 57-68-1; 1981-58-4 |
Sulfamethazine Toxicological Summary for Sulfamethazine (PDF) Information Sheet: Sulfonamide Antibiotics and Drinking Water (PDF) |
HRL15 | Acute | ND | -- |
| Short-term | 100 | Thyroid | |||
| Subchronic | 100* | Thyroid | |||
| Chronic | 100* | Thyroid | |||
| Cancer | NA | -- | |||
| 723-46-6 | Sulfamethoxazole Toxicological Summary for Sulfamethoxazole (PDF) Information Sheet: Sulfonamide Antibiotics and Drinking Water (PDF) |
RAA13 | Acute | ND | -- |
| Short-term | 100 | Thyroid | |||
| Subchronic | 100* | Thyroid | |||
| Chronic | 100* | Thyroid | |||
| Cancer | NA | -- | |||
| 630-20-6 | 1,1,1,2-Tetrachloroethane | HRL93 | Chronic | 70 | Kidney system; Liver system |
| 79-34-5 | 1,1,2,2-Tetrachloroethane | HRL94 | Cancer | 2 | Cancer |
| 127-18-4 | Tetrachloroethylene (PERC or PCE) Toxicological Summary for Tetrachloroethylene (PDF) Information Sheet: Tetrachloroethylene (PCE) and Drinking Water (PDF) |
HRLMCL*** | Chronic | 5 | see USEPA Organic Chemicals table |
| HBV21 | Acute | ND | -- | ||
| Short-term | ND | -- | |||
| Subchronic | 7 | Nervous system | |||
| Chronic | 7** | Nervous system | |||
| Cancer | 4 | Cancer | |||
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| 109-99-9 | Tetrahydrofuran Toxicological Summary for Tetrahydrofuran (PDF) Information Sheet: Tetrahydrofuran and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 600 | Developmental | |||
| Subchronic | 600* | Developmental | |||
| Chronic | 600* | Developmental | |||
| Cancer | ND | -- | |||
| 7440-28-0 | Thallium salts | HRL94 | Chronic | 0.6 | Liver system |
| 153719-23-4 | Thiamethoxam Toxicological Summary for Thiamethoxam (PDF) Information Sheet: Thiamethoxam and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | 400 | Developmental; Female reproductive system; Liver system | |||
| Subchronic | 200 | Male reproductive system | |||
| Chronic | 200** | Male reproductive system | |||
| Cancer | NA | -- | |||
| 7440-31-5 | Tin | HRL94 | Chronic | 4,000 | Liver system; Kidney system |
| 108-88-3 | Toluene Toxicological Summary for Toluene 2011 (PDF) |
HRL11*** | Acute | ND | -- |
| Short-term | 200 | Immune system; Nervous system | |||
| Subchronic | 200* | Immune system; Nervous system | |||
| Chronic | 200* | Immune system; Nervous system | |||
| Cancer | NA | -- | |||
| Toluene Toxicological Summary for Toluene (2020) (PDF) Information Sheet: Toluene and Groundwater (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | 70 | Immune system; Nervous system | |||
| Subchronic | 70* | Immune system; Nervous system | |||
| Chronic | 70* | Immune system; Nervous system | |||
| Cancer | NA | -- | |||
| Not available | Total Petroleum Hydrocarbon. See Other Guidance: Chemical Specific | ||||
| 8001-35-2 | Toxaphene | HRL93 | Cancer | 0.3 | Cancer |
| 120-82-1 | 1,2,4-Trichlorobenzene Toxicological Summary for 1,2,4-Trichlorobenzene (PDF) |
HRL13 | Acute | ND | -- |
| Short-term | 100 | Liver system; Adrenal (E); Blood system | |||
| Subchronic | 100* | Liver system; Adrenal (E); Blood system | |||
| Chronic | 100 | Liver system; Adrenal (E); Kidney system | |||
| Cancer | 4 | Cancer | |||
| 108-70-3 | 1,3,5-Trichlorobenzene Toxicological Summary for 1,3,5-Trichlorobenzene (PDF) |
RAA12 | Acute | ND | -- |
| Short-term | 100 | Liver system; Adrenal (E); Blood System | |||
| Subchronic | 100* | Liver system; Adrenal (E); Blood system | |||
| Chronic | 100 | Liver system; Adrenal (E); Kidney system | |||
| Cancer | 4 | Cancer | |||
| 71-55-6 | 1,1,1-Trichloroethane Toxicological Summary for 1,1,1-Trichloroethane (PDF) Information Sheet: 1,1,1-Trichloroethane and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 9,000 | Liver system; Male reproductive system | |||
| Chronic | 5,000 | Liver system; Male reproductive system | |||
| Cancer | NA | -- | |||
| 79-00-5 | 1,1,2-Trichloroethane | HRL93 | Chronic | 3 | Immune system |
| 79-01-6 | 1,1,2-Trichloroethylene (TCE) Toxicological Summary for 1,1,2-Trichloroethylene (TCE) (PDF) Technical and Application Information Information Sheet: Trichloroethylene (TCE) and Water (PDF) |
HRL15 | Acute | ND | -- |
| Short-term | 0.4 | Developmental; Immune | |||
| Subchronic | 0.4 | Developmental; Immune | |||
| Chronic | 0.4** | Developmental; Immune | |||
| Cancer | 2 | Cancer | |||
| 75-69-4 | Trichlorofluoromethane | HRL93 | Chronic | 2,000 | None |
| 88-06-2 | 2,4,6-Trichlorophenol | HRL93 | Cancer | 30 | Cancer |
| 93-76-5 | 2,4,5-Trichlorophenoxyacetic acid | HRL93 | Chronic | 70 | Developmental; Blood system |
| 93-72-1 | 2-(2,4,5-Trichlorophenoxy) propionic acid | HRLMCL | Chronic | 50 | see USEPA Organic Chemicals table |
| 96-18-4 | 1,2,3-Trichloropropane Toxicological Summary for 1,2,3-Trichloropropane (PDF) Information Sheet: 1,2,3-TCP in Drinking Water (PDF) |
HRL13 | Acute | 7 | Developmental |
| Short-term | 7 | Developmental | |||
| Subchronic | 7* | Developmental | |||
| Chronic | 7* | Developmental | |||
| Cancer | 0.003 | Cancer | |||
| 76-13-1 | 1,1,2-Trichloro-1,2,2-trifluoroethane | HRL93 | Chronic | 200,000 | None |
| 101-20-2 | Triclocarban Toxicological Summary for Triclocarban (PDF) Information Sheet: Triclocarban and Drinking Water (PDF) |
RAA13 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | ND | -- | |||
| Chronic | 100 | Blood system; Liver system; Male reproductive system; Kidney system | |||
| Cancer | NA | -- | |||
| 3380-34-5 | Triclosan Toxicological Summary for Triclosan (PDF) Information Sheet: Triclosan and Drinking Water (PDF) |
HRL15 | Acute | ND | -- |
| Short-term | 50 | Developmental; Liver system; Thyroid (E); Female Reproductive system (E) | |||
| Subchronic | 50* | Developmental; Liver system; Thyroid (E); Female Reproductive system (E) | |||
| Chronic | 50* | Developmental; Liver system; Thyroid (E); Female Reproductive system (E) | |||
| Cancer | NA | -- | |||
| 526-73-8 | 1,2,3-Trimethylbenzene Toxicological Summary for 1,2,4-Trimethylbenzene; 1,3,5-Trimethylbenzene; and 1,2,3-Trimethylbenzene (2020) (PDF) Information Sheet: Trimethylbenzenes and Groundwater (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 30 | Nervous system | |||
| Subchronic | 30* | Nervous system | |||
| Chronic | 30* | Nervous system | |||
| Cancer | NA | -- | |||
| 95-63-6 | 1,2,4-Trimethylbenzene Toxicological Summary for 1,2,4-Trimethylbenzene; 1,3,5-Trimethylbenzene; and 1,2,3-Trimethylbenzene (2020) (PDF) Information Sheet: Trimethylbenzenes and Groundwater (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 30 | Nervous system | |||
| Subchronic | 30* | Nervous system | |||
| Chronic | 30* | Nervous system | |||
| Cancer | NA | -- | |||
| 108-67-8 | 1,3,5-Trimethylbenzene Toxicological Summary for 1,3,5-Trimethylbenzene (2009) (PDF) |
HRL09*** | Acute | ND | -- |
| Short-term | 100 | Liver system | |||
| Subchronic | 100* | Liver system | |||
| Chronic | 100* | Liver system | |||
| Cancer | NA | -- | |||
| 1,3,5-Trimethylbenzene Toxicological Summary for 1,2,4-Trimethylbenzene; 1,3,5-Trimethylbenzene; and 1,2,3-Trimethylbenzene (2020) (PDF) Information Sheet: Trimethylbenzenes and Groundwater (PDF) |
HBV20 | Acute | ND | -- | |
| Short-term | 30 | Nervous system | |||
| Subchronic | 30* | Nervous system | |||
| Chronic | 30* | Nervous system | |||
| Cancer | NA | -- | |||
| 99-35-4 | 1,3,5-Trinitrobenzene | HRL93 | Chronic | 0.3 | None |
| 78-51-3 | Tris(2-butoxyethyl) phosphate (TBEP) Toxicological Summary for Tris(2-butoxyethyl) phosphate (PDF) |
HBV20 | Acute | ND | -- |
| Short-term | 30 | Liver system | |||
| Subchronic | 30* | Liver system | |||
| Chronic | 30 | Liver system | |||
| Cancer | NA | -- | |||
| 115-96-8 | Tris(2-chloroethyl) phosphate (TCEP) Toxicological Summary for Tris(2-chloroethyl)phosphate (PDF) Information Sheet: TCEP in Drinking Water (PDF) |
HRL13 | Acute | ND | -- |
| Short-term | 300 | Developmental; Nervous system; Kidney system | |||
| Subchronic | 200 | Kidney system | |||
| Chronic | 200** | Kidney system | |||
| Cancer | 5 | Cancer | |||
| 13674-87-8 | Tris(1,3-dichloroisopropyl)phosphate (TDCPP) Toxicological Summary for Tris(1,3-dichloroisopropyl)phosphate (PDF) Information Sheet: TDCPP and Drinking Water (PDF) |
HBV21 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 20 | Liver system; Kidney system | |||
| Chronic | 8 | Kidney system; Male reproductive system | |||
| Cancer | 0.8 | Cancer | |||
| 7440-62-2 | Vanadium | HRL94 | Chronic | 50 | None |
| 93413-69-5; 99300-78-4 | Venlafaxine Toxicological Summary for Venlafaxine (PDF) Information Sheet: Venlafaxine and Desvenlafaxine and Drinking Water (PDF) |
HBV22 | Acute | ND | -- |
| Short-term | 10 | Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E) | |||
| Subchronic | 10* | Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E) | |||
| Chronic | 10* | Developmental; Gastrointestinal system; Male reproductive system; Nervous system (E) | |||
| Cancer | NA | -- | |||
| 75-01-4 | Vinyl Chloride Toxicological Summary for Vinyl Chloride (PDF) Information Sheet: Vinyl Chloride and Drinking Water (PDF) |
HRL18 | Acute | ND | -- |
| Short-term | ND | -- | |||
| Subchronic | 90 | Liver system | |||
| Chronic | 10 | Liver system | |||
| Cancer | 0.2 | Cancer | |||
| 1330-20-7 | Xylenes Toxicological Summary for Xylenes (mixture of isomers, o, m, p) (PDF) |
HRL11*** | Acute | 800 | Nervous system |
| Short-term | 300 | Nervous system | |||
| Subchronic | 300* | Kidney system; Nervous system | |||
| Chronic | 300* | Kidney system; Nervous system | |||
| Cancer | NA | -- | |||
| Xylenes Toxicological Summary for Xylenes (2020) (PDF) Information Sheet: Xylenes and Groundwater (PDF) |
HBV20 | Acute | 700 | Nervous system | |
| Short-term | 300 | Developmental; Nervous system | |||
| Subchronic | 300 | Developmental; Nervous system; Kidney system | |||
| Chronic | 300** | Developmental; Nervous system; Kidney system | |||
| Cancer | NA | -- | |||
| 7440-66-6 | Zinc | HRL94 | Chronic | 2,000 | None |
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NA - Not Applicable
ND - Not derived due to insufficient information
None - Nonspecific effects that could not be attributed to an organ system
(E) = Endocrine mediated effect on the specified target organ
*Set at short-term value
**Set at subchronic value
***Dual guidance applies: See Dual Guidance for Drinking Water
For more information about this page, please contact the Environmental Health Division: health.risk@state.mn.us
